Phenotypic comparison between smoking and non-smoking chronic obstructive pulmonary disease

• Published in: Respiratory research Vol. 21; no. 1; pp. 50 - 12
• Main Authors: Salvi, Sundeep S., Brashier, Bill B., Londhe, Jyoti, Pyasi, Kanchan, Vincent, Vandana, Kajale, Shilpa S., Tambe, Sajid, Mandani, Kuldeep, Nair, Arjun, Mak, Sze Mun, Madas, Sapna, Juvekar, Sanjay, Donnelly, Louise E., Barnes, Peter J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.02.2020; BioMed Central; BMC
• Subjects: Age Factors; Aged; Allergic diseases; Asthma; Biomarkers; Biomass; biomass smoke; Blood; Body mass index; Body size; Bronchodilators; Case-Control Studies; Cell size; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comparative analysis; Computed tomography; Corticoids; Corticosteroids; Cross-Sectional Studies; Demographic aspects; Diffusion rate; Emphysema; Eosinophils; Female; Females; Genetic aspects; Health aspects; Hemoglobin; household air pollution; Humans; Immunomodulators; Insulin; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lung diseases; Lungs; Male; Middle Aged; Non-Smokers; non-smoking COPD; Obstructive lung disease; Phenotype; Phenotypes; Physiology; Plethysmography; Population; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of life; Respiration; Respiratory diseases; Respiratory function; Respiratory tract diseases; Rural population; Sex Factors; Signs and symptoms; small airway disease; Smokers; Smoking; Spirometry - methods; Sputum; Statistics; Tobacco Smoking - epidemiology; Tobacco Smoking - physiopathology; India; Chronic obstructive pulmonary disease; biomass smoke; small airway disease; household air pollution; non-smoking COPD

Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clinical, physiological, radiological, sputum cellular and blood biomarkers. Two hundred ninety...