Detecting laryngopharyngeal reflux in patients with upper airways symptoms: Symptoms, signs or salivary pepsin?

• Published in: Respiratory medicine Vol. 109; no. 8; pp. 963 - 969
• Main Authors: Spyridoulias, Alexander, Lillie, Siobhan, Vyas, Aashish, Fowler, Stephen J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2015; Elsevier Limited
• Subjects: Acids; Biomarkers - metabolism; Chronic cough; Cough - diagnosis; Cough - etiology; Cough - metabolism; Diagnosis, Differential; Electric Impedance; Esophageal pH Monitoring; Female; Gastroesophageal reflux; Humans; Hydrogen-Ion Concentration; Inflammation; Laryngopharyngeal reflux; Laryngopharyngeal Reflux - complications; Laryngopharyngeal Reflux - diagnosis; Laryngopharyngeal Reflux - metabolism; Laryngoscopy; Male; Middle Aged; Pepsin; Pepsin A - metabolism; Pulmonary/Respiratory; Saliva - chemistry; Severity of Illness Index; Studies; Vocal cord dysfunction; Vocal Cord Dysfunction - diagnosis; Vocal Cord Dysfunction - etiology; Vocal Cord Dysfunction - metabolism; Vocal cord dysfunction; Laryngopharyngeal reflux; Pepsin; Chronic cough

Laryngopharyngeal reflux (LPR) can induce laryngeal hyper-responsiveness, a unifying feature underlying chronic cough and vocal cord dysfunction. The diagnosis of LPR currently relies on invasive oesophageal pH impedance testing. We compared symptoms, laryngeal signs and salivary pepsin as potential...