Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis

• Published in: Arthritis research & therapy Vol. 20; no. 1; pp. 240 - 10
• Main Authors: Ishikawa, Yuichi, Iwata, Shigeru, Hanami, Kentaro, Nawata, Aya, Zhang, Mingzeng, Yamagata, Kaoru, Hirata, Shintaro, Sakata, Kei, Todoroki, Yasuyuki, Nakano, Kazuhisa, Nakayamada, Shingo, Satoh, Minoru, Tanaka, Yoshiya
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2018; BioMed Central; BMC
• Subjects: Aged; Aged, 80 and over; Arthritis; Biomarkers; Biomarkers - blood; Care and treatment; Chemokines; Complications and side effects; Cytokines; Dermatomyositis; Dermatomyositis - blood; Dermatomyositis - diagnostic imaging; Dermatomyositis - epidemiology; Development and progression; Disease Progression; Female; Genetic aspects; Humans; Hypoxemia; IFN-γ; Immunoglobulins; Intensive care; Interferon; Interferon-gamma - blood; Interstitial lung diseases; Lung diseases; Lung Diseases, Interstitial - blood; Lung Diseases, Interstitial - diagnostic imaging; Lung Diseases, Interstitial - epidemiology; Lungs; Lymphatic system; Male; Medical prognosis; Middle Aged; Mortality; Pathogenesis; Patients; Rapidly progressive interstitial lung disease; Rheumatology; Risk factors; Sepsis; Severity of Illness Index; Spleen; Time Factors; Tomography; Tomography, X-Ray Computed - methods; Tumor necrosis factor-TNF; Japan; IFN-γ; Rapidly progressive interstitial lung disease; Dermatomyositis

Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD) is a life-threatening condition. Serum cytokine levels are potentially suitable biomarkers for DM RP-ILD. However, the relationships among cytokine levels, lung imaging findings, and lung pathology have not been inve...