Molecular crosstalk between p70S6k and MAPK cell signaling pathways
We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated MAPK activity but also partially inactivated the ribosomal kinase p70S6K. Since a connection between the two major si...
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Published in | Biochemical and biophysical research communications Vol. 293; no. 1; pp. 463 - 469 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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Elsevier Inc
26.04.2002
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Abstract | We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated MAPK activity but also partially inactivated the ribosomal kinase p70S6K. Since a connection between the two major signaling pathways, Ras/MEK/MAPK and PI3-K/p70S6K was suspected, experiments were designed to prove a molecular crosstalk between those. First, p70S6K protein could be co-immunoprecipitated with anti-MAPK antibodies, MAPK protein was similarly present in anti-p70S6K immunoprecipitates, indicating close spatial proximity of both signaling molecules. Second, p70S6K enzymatic activity was found in anti-MAPK immunoprecipitates and MAPK in anti-p70S6K immunoprecipitates, being the latter activity higher in samples derived from GM-CSF-treated cells. Since an upstream activator of p70S6K, phosphatidylinositol (PI)3-kinase, has been associated to cell movement in phagocytic cells, we studied a possible participation of p70S6K in chemotaxis and whether MAPK had an input. Our data show that functional chemotaxis was inhibited by rapamycin, a specific p70S6K inhibitor, as well as by PD-98059. Thus, a connection between these two kinases extends from the molecular level to cell migration, a key functionality in non-proliferative, mature phagocytes such as neutrophils. |
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AbstractList | We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated MAPK activity but also partially inactivated the ribosomal kinase p70S6K. Since a connection between the two major signaling pathways, Ras/MEK/MAPK and PI3-K/p70S6K was suspected, experiments were designed to prove a molecular crosstalk between those. First, p70S6K protein could be co-immunoprecipitated with anti-MAPK antibodies, MAPK protein was similarly present in anti-p70S6K immunoprecipitates, indicating close spatial proximity of both signaling molecules. Second, p70S6K enzymatic activity was found in anti-MAPK immunoprecipitates and MAPK in anti-p70S6K immunoprecipitates, being the latter activity higher in samples derived from GM-CSF-treated cells. Since an upstream activator of p70S6K, phosphatidylinositol (PI)3-kinase, has been associated to cell movement in phagocytic cells, we studied a possible participation of p70S6K in chemotaxis and whether MAPK had an input. Our data show that functional chemotaxis was inhibited by rapamycin, a specific p70S6K inhibitor, as well as by PD-98059. Thus, a connection between these two kinases extends from the molecular level to cell migration, a key functionality in non-proliferative, mature phagocytes such as neutrophils. We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, not only completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)- stimulated MAPK activity, but it also partially (~70%) inactivated the ribosomal kinase p70S6K. Since a connection between the two major signaling pathways, Ras/MEK/MAPK and PI3-K/p70S6K was suspected, experiments were designed to prove a molecular crosstalk between them. First, p70S6K protein was detected in anti-MAPK immunoprecipitates; MAPK protein was similarly co-immunoprecipitated with anti-p70S6K antibodies, indicating a close spatial proximity of both signaling molecules. Second, p70S6K enzymatic activity was found in anti-MAPK immunopcomplexes and, likewise, MAPK activity was present in anti-p70S6K immunoprecipitates, being the latter activity higher in samples derived from GM-CSF-treated cells than in untreated samples. Since an upstream activator of p70S6K, phosphatidylinositol (PI)3-kinase, has been associated with cell movement in phagocytic cells, we studied whether MAPK had a role in neutrophil migration. Our data showed that functional chemotaxis was partially inhibited by PD-98059, as well as by rapamycin, a specific inhibitor of mTOR (upstream of p70S6K), and almost totally (~90%) by a combination of the two. In summary, a molecular connection between the MAPK and the p70S6K pathways exists, with the former exerting a positive feedback on the latter upon GM-CSF stimulation, and this leads to non-proliferative responses such as chemotaxis. We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated MAPK activity but also partially inactivated the ribosomal kinase p70S6K. Since a connection between the two major signaling pathways, Ras/MEK/MAPK and PI3-K/p70S6K was suspected, experiments were designed to prove a molecular crosstalk between those. First, p70S6K protein could be co-immunoprecipitated with anti-MAPK antibodies, MAPK protein was similarly present in anti-p70S6K immunoprecipitates, indicating close spatial proximity of both signaling molecules. Second, p70S6K enzymatic activity was found in anti-MAPK immunoprecipitates and MAPK in anti-p70S6K immunoprecipitates, being the latter activity higher in samples derived from GM-CSF-treated cells. Since an upstream activator of p70S6K, phosphatidylinositol (PI)3-kinase, has been associated to cell movement in phagocytic cells, we studied a possible participation of p70S6K in chemotaxis and whether MAPK had an input. Our data show that functional chemotaxis was inhibited by rapamycin, a specific p70S6K inhibitor, as well as by PD-98059. Thus, a connection between these two kinases extends from the molecular level to cell migration, a key functionality in non-proliferative, mature phagocytes such as neutrophils. [copy ] 2002 Elsevier Science (USA) |
Author | Lehman, Jason A Gomez-Cambronero, Julian |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12054624$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1126/science.286.5445.1741 10.1016/S0014-5793(97)00323-2 10.1006/bbrc.1999.1833 10.1093/oxfordjournals.jbchem.a022067 10.1016/S0014-5793(99)01434-9 10.1074/jbc.274.31.22033 10.1038/377441a0 10.1126/science.286.5445.1738 10.1016/S0021-9258(18)98436-X 10.1016/S0960-9822(06)00122-9 10.1074/jbc.274.9.5333 10.4049/jimmunol.160.4.1982 10.1046/j.1440-1711.2000.00928.x 10.1128/MCB.19.12.8344 10.1016/S0968-0004(96)10016-5 10.1002/eji.1830241115 10.1126/science.279.5351.707 10.1074/jbc.271.22.13088 10.1074/jbc.271.35.21005 10.1073/pnas.89.16.7551 10.1074/jbc.272.22.14426 10.1074/jbc.270.46.27489 10.1073/pnas.89.16.7571 10.1073/pnas.92.17.7686 10.1074/jbc.273.8.4776 10.1006/bbrc.1997.7163 10.1016/S0021-9258(19)50735-9 10.1073/pnas.95.9.5033 10.1038/sj.onc.1204994 10.1128/MCB.17.8.4406 10.1093/emboj/16.12.3693 10.1139/o96-064 10.1152/ajpcell.2001.280.1.C183 10.1016/S0021-9258(19)77655-8 10.1083/jcb.145.4.727 |
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Keywords | p70S6K Ribosomal kinase GM-CSF Chemotaxis Cell signaling Neutrophils |
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References | Scheid, Charlton, Pelech, Duronio (BIB6) 1996; 74 Reif, Burgering, Kantrell (BIB9) 1997; 272 Pullen, Thomas (BIB3) 1997; 410 Berven, Crouch (BIB33) 2000; 78 Pullen, Dennis, Andjelkovic, Duffner, Kozma, Hemmings, Thomas (BIB14) 1998; 279 Joseph, Paul, Baumann, Gomez-Cambronero (BIB19) 1996; 271 Al-Shami, Naccache (BIB20) 1999; 274 Berven, Frew, Crouch (BIB32) 1999; 266 Fukui, Ihara, Nagata (BIB11) 1998; 124 Hayashi, Takahashi, Kimura, Nishida, Saga, Sobue (BIB22) 1999; 145 Kennelly, Krebs (BIB35) 1991; 266 Dudley, Pang, Decker, Bridges, Saltiel (BIB25) 1995; 92 Zimmermann, Moelling (BIB30) 1999; 286 Calvo, Crews, Vik, Bierer (BIB7) 1992; 89 Lehman, Paul, Baumann, Gomez-Cambronero (BIB17) 2001; 280 Gille, Downward (BIB23) 1999; 274 Alessi, Cuenda, Cohen, Dudley, Saltiel (BIB24) 1995; 270 Brown, Beal, Keith, Chen, Shin, Schreiber (BIB10) 1995; 377 Seva, Kowalski-Chauvel, Daulhac, Barthez, Vaysse, Pradayrol (BIB28) 1997; 238 Jefferies, Fumagalli, Dennis, Reinhard, Pearson, Thomas (BIB4) 1997; 16 Calvo, Wood, Gjerston, Vik, Bierer (BIB8) 1994; 24 Proud (BIB2) 1996; 21 Downey, Butler, Brumell, Borregaard, Kjeldsen, Sue-A-Quan, Grinstein (BIB15) 1996; 271 Shaw, Cohen (BIB21) 1999; 461 Pardo, Arcaro, Salerno, Tetley, Valovka, Gout, Seckl (BIB34) 2001; 20 Gomez-Cambronero, Huang, Gomez-Cambronero, Waterman, Becker, Sha'afi (BIB18) 1992; 89 King, Mattaliano, Chan, Tsichlis, Brugge (BIB26) 1997; 17 Alessi, James, Downes, Holmes, Gaffney, Reese (BIB12) 1997; 7 Rommel, Clarke, Zimmermann, Nunez, Rossman, Reid, Moelling, Yancopoulos, Glass (BIB29) 1999; 286 Zu, Qi, Gilchrist, Fernandez, Vazquez-Abad, Kreutzer, Huang, Sha'afi (BIB16) 1998; 160 Conus, Hemmings, Pearson (BIB13) 1998; 273 Inagaki, Schmelzle, Yamaguchi, Irie, Hall, Matsumoto (BIB27) 1999; 19 Kawasome, Papst, Webb, Keller, Johnson, Gelfand (BIB5) 1998; 95 Mukhopadhyay, Price, Kyriakis, Pelech, Sanghera, Avruch (BIB31) 1992; 267 Nemenoff, Price, Mendelsohn, Carter, Avruch (BIB1) 1988; 263 10330402 - J Cell Biol. 1999 May 17;145(4):727-40 2848828 - J Biol Chem. 1988 Dec 25;263(36):19455-60 10600507 - Biochem Biophys Res Commun. 1999 Dec 20;266(2):352-60 1323842 - Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7551-5 9162082 - J Biol Chem. 1997 May 30;272(22):14426-33 10419529 - J Biol Chem. 1999 Jul 30;274(31):22033-40 10561508 - FEBS Lett. 1999 Nov 12;461(1-2):120-4 1737788 - J Biol Chem. 1992 Feb 15;267(5):3325-35 9094314 - Curr Biol. 1997 Apr 1;7(4):261-9 8960366 - Biochem Cell Biol. 1996;74(4):595-600 11121390 - Am J Physiol Cell Physiol. 2001 Jan;280(1):C183-91 9445476 - Science. 1998 Jan 30;279(5351):707-10 10947872 - Immunol Cell Biol. 2000 Aug;78(4):447-51 8871403 - Trends Biochem Sci. 1996 May;21(5):181-5 10576742 - Science. 1999 Nov 26;286(5445):1741-4 7644477 - Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9 1380162 - Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7571-5 9560223 - Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5033-8 8662788 - J Biol Chem. 1996 May 31;271(22):13088-93 9468542 - J Biol Chem. 1998 Feb 20;273(8):4776-82 11753643 - Oncogene. 2001 Nov 15;20(52):7658-67 7957559 - Eur J Immunol. 1994 Nov;24(11):2664-71 8702863 - J Biol Chem. 1996 Aug 30;271(35):21005-1011 10567559 - Mol Cell Biol. 1999 Dec;19(12):8344-52 10576741 - Science. 1999 Nov 26;286(5445):1738-41 7566123 - Nature. 1995 Oct 5;377(6548):441-6 7499206 - J Biol Chem. 1995 Nov 17;270(46):27489-94 9234699 - Mol Cell Biol. 1997 Aug;17(8):4406-18 9247127 - FEBS Lett. 1997 Jun 23;410(1):78-82 9218810 - EMBO J. 1997 Jun 16;16(12):3693-704 10026141 - J Biol Chem. 1999 Feb 26;274(9):5333-8 9299479 - Biochem Biophys Res Commun. 1997 Sep 8;238(1):202-6 9644237 - J Biochem. 1998 Jul;124(1):1-7 1651913 - J Biol Chem. 1991 Aug 25;266(24):15555-8 9469462 - J Immunol. 1998 Feb 15;160(4):1982-9 Proud (10.1016/S0006-291X(02)00238-3_BIB2) 1996; 21 Rommel (10.1016/S0006-291X(02)00238-3_BIB29) 1999; 286 Downey (10.1016/S0006-291X(02)00238-3_BIB15) 1996; 271 King (10.1016/S0006-291X(02)00238-3_BIB26) 1997; 17 Berven (10.1016/S0006-291X(02)00238-3_BIB32) 1999; 266 Fukui (10.1016/S0006-291X(02)00238-3_BIB11) 1998; 124 Alessi (10.1016/S0006-291X(02)00238-3_BIB12) 1997; 7 Reif (10.1016/S0006-291X(02)00238-3_BIB9) 1997; 272 Nemenoff (10.1016/S0006-291X(02)00238-3_BIB1) 1988; 263 Scheid (10.1016/S0006-291X(02)00238-3_BIB6) 1996; 74 Zu (10.1016/S0006-291X(02)00238-3_BIB16) 1998; 160 Pullen (10.1016/S0006-291X(02)00238-3_BIB14) 1998; 279 Dudley (10.1016/S0006-291X(02)00238-3_BIB25) 1995; 92 Hayashi (10.1016/S0006-291X(02)00238-3_BIB22) 1999; 145 Calvo (10.1016/S0006-291X(02)00238-3_BIB7) 1992; 89 Kennelly (10.1016/S0006-291X(02)00238-3_BIB35) 1991; 266 Conus (10.1016/S0006-291X(02)00238-3_BIB13) 1998; 273 Gille (10.1016/S0006-291X(02)00238-3_BIB23) 1999; 274 Al-Shami (10.1016/S0006-291X(02)00238-3_BIB20) 1999; 274 Pardo (10.1016/S0006-291X(02)00238-3_BIB34) 2001; 20 Calvo (10.1016/S0006-291X(02)00238-3_BIB8) 1994; 24 Seva (10.1016/S0006-291X(02)00238-3_BIB28) 1997; 238 Brown (10.1016/S0006-291X(02)00238-3_BIB10) 1995; 377 Joseph (10.1016/S0006-291X(02)00238-3_BIB19) 1996; 271 Gomez-Cambronero (10.1016/S0006-291X(02)00238-3_BIB18) 1992; 89 Alessi (10.1016/S0006-291X(02)00238-3_BIB24) 1995; 270 Lehman (10.1016/S0006-291X(02)00238-3_BIB17) 2001; 280 Mukhopadhyay (10.1016/S0006-291X(02)00238-3_BIB31) 1992; 267 Berven (10.1016/S0006-291X(02)00238-3_BIB33) 2000; 78 Shaw (10.1016/S0006-291X(02)00238-3_BIB21) 1999; 461 Pullen (10.1016/S0006-291X(02)00238-3_BIB3) 1997; 410 Inagaki (10.1016/S0006-291X(02)00238-3_BIB27) 1999; 19 Jefferies (10.1016/S0006-291X(02)00238-3_BIB4) 1997; 16 Kawasome (10.1016/S0006-291X(02)00238-3_BIB5) 1998; 95 Zimmermann (10.1016/S0006-291X(02)00238-3_BIB30) 1999; 286 |
References_xml | – volume: 286 start-page: 1741 year: 1999 end-page: 1744 ident: BIB30 article-title: Phosphorylation and regulation of Raf by Akt (Protein kinase B) publication-title: Science contributor: fullname: Moelling – volume: 7 start-page: 261 year: 1997 end-page: 269 ident: BIB12 article-title: 3-Phosphoinositide-dependent protein kinase-1 (PDK-1): structural and functional homology with the Drosophila DSTPK61 kinase publication-title: Curr. Biol. contributor: fullname: Reese – volume: 274 start-page: 22033 year: 1999 end-page: 22040 ident: BIB23 article-title: Multiple ras effector pathways contribute to G(1) cell cycle progression publication-title: J. Biol. Chem. contributor: fullname: Downward – volume: 286 start-page: 1738 year: 1999 end-page: 1741 ident: BIB29 article-title: Differentiation stage-specific inhibition of the Raf–Mek–Erk pathway by Akt publication-title: Science contributor: fullname: Glass – volume: 270 start-page: 27489 year: 1995 end-page: 27494 ident: BIB24 article-title: PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo publication-title: J. Biol. Chem. contributor: fullname: Saltiel – volume: 19 start-page: 8344 year: 1999 end-page: 8352 ident: BIB27 article-title: PDK1 homologs activate the PKC1-Mitogen-activated protein kinase pathway in yeast publication-title: Mol. Cell Biol. contributor: fullname: Matsumoto – volume: 95 start-page: 5033 year: 1998 end-page: 5038 ident: BIB5 article-title: Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Gelfand – volume: 21 start-page: 181 year: 1996 end-page: 185 ident: BIB2 article-title: p70 S6 kinase: an enigma with variations publication-title: Trends Biochem. Sci. contributor: fullname: Proud – volume: 280 start-page: 183 year: 2001 end-page: 191 ident: BIB17 article-title: MAP kinase upregulation after hematopoietic differentiation: role of chemotaxis publication-title: Am. J. Physiol. Cell Physiol. contributor: fullname: Gomez-Cambronero – volume: 78 start-page: 447 year: 2000 end-page: 451 ident: BIB33 article-title: Cellular function of p70S6K: A role in regulating cell motility publication-title: Immunol. Cell Biol. contributor: fullname: Crouch – volume: 272 start-page: 14426 year: 1997 end-page: 14433 ident: BIB9 article-title: Phosphotidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase publication-title: J. Biol. Chem. contributor: fullname: Kantrell – volume: 160 start-page: 1982 year: 1998 end-page: 1989 ident: BIB16 article-title: p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-a or FMLP stimulation publication-title: J. Immunol. contributor: fullname: Sha'afi – volume: 16 start-page: 3693 year: 1997 end-page: 3704 ident: BIB4 article-title: Rapamycin suppresses 5 publication-title: EMBO J. contributor: fullname: Thomas – volume: 124 start-page: 1 year: 1998 end-page: 7 ident: BIB11 article-title: Downstream of phosphotidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses publication-title: J. Biochem. contributor: fullname: Nagata – volume: 20 start-page: 7658 year: 2001 end-page: 7667 ident: BIB34 article-title: Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells publication-title: Oncogene contributor: fullname: Seckl – volume: 266 start-page: 352 year: 1999 end-page: 360 ident: BIB32 article-title: Nitric oxide donors selectively potentiate thrombin-stimulated p70S6K activity and morphological changes in Swiss 3T3 cells publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Crouch – volume: 410 start-page: 78 year: 1997 end-page: 82 ident: BIB3 article-title: The modular phosphorylation and activation of p70S6K publication-title: FEBS Lett. contributor: fullname: Thomas – volume: 89 start-page: 7571 year: 1992 end-page: 7575 ident: BIB7 article-title: Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Bierer – volume: 267 start-page: 3325 year: 1992 end-page: 3335 ident: BIB31 article-title: An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase publication-title: J. Biol. Chem. contributor: fullname: Avruch – volume: 377 start-page: 441 year: 1995 end-page: 446 ident: BIB10 article-title: Control of p70 s6 kinase by kinase activity of FRAP in vivo publication-title: Nature contributor: fullname: Schreiber – volume: 461 start-page: 120 year: 1999 end-page: 124 ident: BIB21 article-title: Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells publication-title: FEBS Lett. contributor: fullname: Cohen – volume: 74 start-page: 595 year: 1996 end-page: 600 ident: BIB6 article-title: Role of p70 S6 kinase in cytokine-regulated hematopoietic cell survival publication-title: Biochem. Cell Biol. contributor: fullname: Duronio – volume: 274 start-page: 5333 year: 1999 end-page: 5338 ident: BIB20 article-title: Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase publication-title: J. Biol. Chem. contributor: fullname: Naccache – volume: 145 start-page: 727 year: 1999 end-page: 770 ident: BIB22 article-title: Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells publication-title: J. Cell Biol. contributor: fullname: Sobue – volume: 266 start-page: 15555 year: 1991 end-page: 15558 ident: BIB35 article-title: Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases publication-title: J. Biol. Chem. contributor: fullname: Krebs – volume: 24 start-page: 2664 year: 1994 end-page: 2671 ident: BIB8 article-title: Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation publication-title: Eur. J. Immunol. contributor: fullname: Bierer – volume: 273 start-page: 4776 year: 1998 end-page: 4782 ident: BIB13 article-title: Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k publication-title: J. Biol. Chem. contributor: fullname: Pearson – volume: 89 start-page: 7551 year: 1992 end-page: 7555 ident: BIB18 article-title: Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of MAP Kinase in human neutrophils publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Sha'afi – volume: 92 start-page: 7686 year: 1995 end-page: 7689 ident: BIB25 article-title: A synthetic inhibitor of the mitogen-activated protein kinase cascade publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Saltiel – volume: 271 start-page: 21005 year: 1996 end-page: 21011 ident: BIB15 article-title: Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin publication-title: J. Biol. Chem. contributor: fullname: Grinstein – volume: 279 start-page: 707 year: 1998 end-page: 710 ident: BIB14 article-title: Phosphorylation and activation of p70s6k by PDK1 publication-title: Science contributor: fullname: Thomas – volume: 17 start-page: 4406 year: 1997 end-page: 4418 ident: BIB26 article-title: Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/Mitogen-activated protein kinase pathway activation publication-title: Mol. Cell Biol. contributor: fullname: Brugge – volume: 263 start-page: 19455 year: 1988 end-page: 19460 ident: BIB1 article-title: An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells publication-title: J. Biol. Chem. contributor: fullname: Avruch – volume: 271 start-page: 13088 year: 1996 end-page: 13093 ident: BIB19 article-title: S6 kinase p90 publication-title: J. Biol. Chem. contributor: fullname: Gomez-Cambronero – volume: 238 start-page: 202 year: 1997 end-page: 206 ident: BIB28 article-title: Wormannin-sensitive activation of p70S6-kinase and MAP-kinase by the G protein-coupled receptor, G/CCKb publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Pradayrol – volume: 286 start-page: 1741 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB30 article-title: Phosphorylation and regulation of Raf by Akt (Protein kinase B) publication-title: Science doi: 10.1126/science.286.5445.1741 contributor: fullname: Zimmermann – volume: 410 start-page: 78 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB3 article-title: The modular phosphorylation and activation of p70S6K publication-title: FEBS Lett. doi: 10.1016/S0014-5793(97)00323-2 contributor: fullname: Pullen – volume: 266 start-page: 352 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB32 article-title: Nitric oxide donors selectively potentiate thrombin-stimulated p70S6K activity and morphological changes in Swiss 3T3 cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1999.1833 contributor: fullname: Berven – volume: 124 start-page: 1 year: 1998 ident: 10.1016/S0006-291X(02)00238-3_BIB11 article-title: Downstream of phosphotidylinositol-3 kinase, a multifunctional signaling molecule, and its regulation in cell responses publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a022067 contributor: fullname: Fukui – volume: 461 start-page: 120 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB21 article-title: Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)01434-9 contributor: fullname: Shaw – volume: 274 start-page: 22033 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB23 article-title: Multiple ras effector pathways contribute to G(1) cell cycle progression publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.31.22033 contributor: fullname: Gille – volume: 377 start-page: 441 year: 1995 ident: 10.1016/S0006-291X(02)00238-3_BIB10 article-title: Control of p70 s6 kinase by kinase activity of FRAP in vivo publication-title: Nature doi: 10.1038/377441a0 contributor: fullname: Brown – volume: 286 start-page: 1738 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB29 article-title: Differentiation stage-specific inhibition of the Raf–Mek–Erk pathway by Akt publication-title: Science doi: 10.1126/science.286.5445.1738 contributor: fullname: Rommel – volume: 266 start-page: 15555 year: 1991 ident: 10.1016/S0006-291X(02)00238-3_BIB35 article-title: Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)98436-X contributor: fullname: Kennelly – volume: 7 start-page: 261 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB12 article-title: 3-Phosphoinositide-dependent protein kinase-1 (PDK-1): structural and functional homology with the Drosophila DSTPK61 kinase publication-title: Curr. Biol. doi: 10.1016/S0960-9822(06)00122-9 contributor: fullname: Alessi – volume: 274 start-page: 5333 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB20 article-title: Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.9.5333 contributor: fullname: Al-Shami – volume: 160 start-page: 1982 year: 1998 ident: 10.1016/S0006-291X(02)00238-3_BIB16 article-title: p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-a or FMLP stimulation publication-title: J. Immunol. doi: 10.4049/jimmunol.160.4.1982 contributor: fullname: Zu – volume: 78 start-page: 447 year: 2000 ident: 10.1016/S0006-291X(02)00238-3_BIB33 article-title: Cellular function of p70S6K: A role in regulating cell motility publication-title: Immunol. Cell Biol. doi: 10.1046/j.1440-1711.2000.00928.x contributor: fullname: Berven – volume: 19 start-page: 8344 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB27 article-title: PDK1 homologs activate the PKC1-Mitogen-activated protein kinase pathway in yeast publication-title: Mol. Cell Biol. doi: 10.1128/MCB.19.12.8344 contributor: fullname: Inagaki – volume: 21 start-page: 181 year: 1996 ident: 10.1016/S0006-291X(02)00238-3_BIB2 article-title: p70 S6 kinase: an enigma with variations publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(96)10016-5 contributor: fullname: Proud – volume: 24 start-page: 2664 year: 1994 ident: 10.1016/S0006-291X(02)00238-3_BIB8 article-title: Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830241115 contributor: fullname: Calvo – volume: 279 start-page: 707 year: 1998 ident: 10.1016/S0006-291X(02)00238-3_BIB14 article-title: Phosphorylation and activation of p70s6k by PDK1 publication-title: Science doi: 10.1126/science.279.5351.707 contributor: fullname: Pullen – volume: 271 start-page: 13088 year: 1996 ident: 10.1016/S0006-291X(02)00238-3_BIB19 article-title: S6 kinase p90rsk in GM-CSF-stimulated proliferative & mature hemopoietic cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.22.13088 contributor: fullname: Joseph – volume: 271 start-page: 21005 year: 1996 ident: 10.1016/S0006-291X(02)00238-3_BIB15 article-title: Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.35.21005 contributor: fullname: Downey – volume: 89 start-page: 7551 year: 1992 ident: 10.1016/S0006-291X(02)00238-3_BIB18 article-title: Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of MAP Kinase in human neutrophils publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.89.16.7551 contributor: fullname: Gomez-Cambronero – volume: 272 start-page: 14426 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB9 article-title: Phosphotidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.22.14426 contributor: fullname: Reif – volume: 270 start-page: 27489 year: 1995 ident: 10.1016/S0006-291X(02)00238-3_BIB24 article-title: PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.46.27489 contributor: fullname: Alessi – volume: 89 start-page: 7571 year: 1992 ident: 10.1016/S0006-291X(02)00238-3_BIB7 article-title: Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.89.16.7571 contributor: fullname: Calvo – volume: 92 start-page: 7686 year: 1995 ident: 10.1016/S0006-291X(02)00238-3_BIB25 article-title: A synthetic inhibitor of the mitogen-activated protein kinase cascade publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.17.7686 contributor: fullname: Dudley – volume: 273 start-page: 4776 year: 1998 ident: 10.1016/S0006-291X(02)00238-3_BIB13 article-title: Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.8.4776 contributor: fullname: Conus – volume: 238 start-page: 202 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB28 article-title: Wormannin-sensitive activation of p70S6-kinase and MAP-kinase by the G protein-coupled receptor, G/CCKb publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.7163 contributor: fullname: Seva – volume: 267 start-page: 3325 year: 1992 ident: 10.1016/S0006-291X(02)00238-3_BIB31 article-title: An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)50735-9 contributor: fullname: Mukhopadhyay – volume: 95 start-page: 5033 year: 1998 ident: 10.1016/S0006-291X(02)00238-3_BIB5 article-title: Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.9.5033 contributor: fullname: Kawasome – volume: 20 start-page: 7658 year: 2001 ident: 10.1016/S0006-291X(02)00238-3_BIB34 article-title: Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells publication-title: Oncogene doi: 10.1038/sj.onc.1204994 contributor: fullname: Pardo – volume: 17 start-page: 4406 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB26 article-title: Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/Mitogen-activated protein kinase pathway activation publication-title: Mol. Cell Biol. doi: 10.1128/MCB.17.8.4406 contributor: fullname: King – volume: 16 start-page: 3693 year: 1997 ident: 10.1016/S0006-291X(02)00238-3_BIB4 article-title: Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k publication-title: EMBO J. doi: 10.1093/emboj/16.12.3693 contributor: fullname: Jefferies – volume: 74 start-page: 595 year: 1996 ident: 10.1016/S0006-291X(02)00238-3_BIB6 article-title: Role of p70 S6 kinase in cytokine-regulated hematopoietic cell survival publication-title: Biochem. Cell Biol. doi: 10.1139/o96-064 contributor: fullname: Scheid – volume: 280 start-page: 183 year: 2001 ident: 10.1016/S0006-291X(02)00238-3_BIB17 article-title: MAP kinase upregulation after hematopoietic differentiation: role of chemotaxis publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.2001.280.1.C183 contributor: fullname: Lehman – volume: 263 start-page: 19455 year: 1988 ident: 10.1016/S0006-291X(02)00238-3_BIB1 article-title: An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)77655-8 contributor: fullname: Nemenoff – volume: 145 start-page: 727 year: 1999 ident: 10.1016/S0006-291X(02)00238-3_BIB22 article-title: Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells publication-title: J. Cell Biol. doi: 10.1083/jcb.145.4.727 contributor: fullname: Hayashi |
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Snippet | We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating... We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, not only completely knocked out granulocyte-macrophage... |
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SubjectTerms | Amino Acid Sequence Cell Division - drug effects Cell signaling Chemotaxis Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - physiology Enzyme Inhibitors - pharmacology Flavonoids - pharmacology GM-CSF Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - physiology p70S6K Ribosomal kinase Phosphorylation Receptor Cross-Talk - physiology Recombinant Proteins Ribosomal Protein S6 Kinases - metabolism Ribosomes - physiology Substrate Specificity Tetradecanoylphorbol Acetate - pharmacology |
Title | Molecular crosstalk between p70S6k and MAPK cell signaling pathways |
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