Is the reaction catalyzed by 3-hydroxy-3-methylglutaryl coenzyme A reductase a rate-limiting step for isoprenoid biosynthesis in plants?

• Published in: Plant physiology (Bethesda) Vol. 109; no. 4; pp. 1337 - 1343
• Main Authors: CHAPPELL, J, WOLF, F, PROULX, J, CUELLAR, R, SAUNDERS, C
• Format: Journal Article
• Language: English
• Published: Rockville, MD American Society of Plant Physiologists 01.12.1995
• Subjects: acide organique; acidos organicos; aciltransferasa; actividad enzimatica; activite enzymatique; acyltransferase; acyltransferases; adn recombinado; adn recombine; biochemical pathways; Biochemistry and Enzymology; Biological and medical sciences; biosintesis; biosynthese; Biosynthesis; Coenzymes; duracion; duration; duree; Enzyme activity; enzyme precursors; Enzymes; enzymic activity; esteroles; expresion genica; expression des genes; Fundamental and applied biological sciences. Psychology; gene expression; Leaves; lipide; lipidos; lipids; Metabolism; Metabolism. Physicochemical requirements; metabolite; metabolites; metabolitos; nicotiana tabacum; organic acids; oxidoreductases; oxidorreductasas; oxydoreductase; Plant physiology and development; plantas transgenicas; plante transgenique; Plants; precurseur d' enzyme; precursores de enzimas; recombinant dna; Sesquiterpenes; sterol; Sterols; Terpenoids; Transgenic plants; via bioquimica del metabolismo; voie biochimique du metabolisme; Agrobacterium tumefaciens; Gene overexpression; Biosynthesis; Nicotiana tabacum; Regulation(control); Enzymatic activity; Dicotyledones; Angiospermae; Bacteria; Chemical composition; Transgenic plant; Solanaceae; Secondary metabolism; Enzyme; Rodentia; Isoprenoid; Vertebrata; Mammalia; Hydroxymethylglutaryl-CoA reductase; Spermatophyta; Oxidoreductases; Rhizobiaceae; Biological accumulation; Hamster; Sterol

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate and is considered a key regulatory step controlling isoprenoid metabolism in mammals and fungi. The rate-limiting nature of this enzyme for isoprenoid b...