Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects

• Published in: European journal of nuclear medicine and molecular imaging Vol. 43; no. 1; pp. 173 - 183
• Main Authors: Collste, K., Forsberg, A., Varrone, A., Amini, N., Aeinehband, S., Yakushev, I., Halldin, C., Farde, L., Cervenka, S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2016; Springer Nature B.V
• Subjects: Brain; Brain imaging; C-11; Carbon Radioisotopes; Cardiology; Female; Genotype; Healthy Volunteers; Humans; Imaging; Male; Medical imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original Article; Orthopedics; PBR28; PET; Protein Binding; Proteins; Pyrimidines - metabolism; Radiology; Receptors, GABA - genetics; Receptors, GABA - metabolism; Reproducibility of Results; Test-retest; Young Adult; PBR28; Test–retest; C; Brain imaging; PET; 11C

Purpose The PET radioligand [ 11 C]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation. We examined the reproducibility of [ 11 C]PBR28 binding in healthy subjects with quantification on a regional and voxel-by-voxel basis. In addition, we performed a preliminary anal...