CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

• Published in: Journal of neuroinflammation Vol. 16; no. 1; pp. 57 - 13
• Main Authors: Tradtrantip, Lukmanee, Duan, Tianjiao, Yeaman, Michael R., Verkman, Alan S.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.03.2019; BioMed Central; BMC
• Subjects: Animal models; Animals; Aquaporin 4; Aquaporin 4 - immunology; Aquaporins; Arthritis; Astrocyte; Astrocytes; Astrocytes - metabolism; Atorvastatin; Autoantibodies; Biotechnology; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain research; Care and treatment; CD55; CD55 Antigens - metabolism; CD59 antigen; Cell culture; Cell Line, Transformed; Cholesterol; Complement-dependent cytotoxicity; Cytotoxicity; Demyelinating diseases; Demyelination; Development and progression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Endothelium; Enzyme-linked immunosorbent assay; fas Receptor - metabolism; Fluvastatin; Functional foods & nutraceuticals; Health aspects; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Immune response; Immunofluorescence; Immunoglobulin G; Immunoglobulin G - administration & dosage; Immunoglobulins; Immunomodulation; Kinases; Lovastatin; Mice; Nervous system; Neuromyelitis; Neuromyelitis optica; Neuromyelitis Optica - drug therapy; Neuromyelitis Optica - metabolism; Neuromyelitis Optica - pathology; NMO; Observations; Pathology; Protein expression; Protein folding; Proteins; RNA, Messenger - metabolism; Simvastatin; Spinal cord; Spinal Cord - drug effects; Spinal Cord - metabolism; Statins; Systematic review; Transcription; Transcriptional Activation - drug effects; Trends; Up-regulation; Up-Regulation - drug effects; United States; NMO; Aquaporin-4; Astrocyte; CD55; Statins; Complement-dependent cytotoxicity

Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflammation. The increased...