Barrett’s oESophagus trial 3 (BEST3): study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux - Offman, Judith; Muldrew, Beth; O’Donovan, Maria; Debiram-Beecham, Irene; Pesola, Francesca; Kaimi, Irene; Smith, Samuel G.; Wilson, Ashley; Khan, Zohrah; Lao-Sirieix, Pierre; Aigret, Benoit; Walter, Fiona M.; et al. (BMC cancer, 2018)
Keywords: Acid reflux; Acids; Analysis; Barrett esophagus; Barrett Esophagus - diagnosis; Barrett Esophagus - etiology; Barrett's esophagus; Biological markers; Biomarker; Biomarkers; Cancer; Chronic Disease; Clinical trials; Diagnosis; Disease Progression; Early detection; Early Detection of Cancer - methods; Endoscopy; Endoscopy, Digestive System - instrumentation; Endoscopy, Digestive System - methods; Equipment Design; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophagus; Female; Gastroenterology; Gastroesophageal reflux; Gastroesophageal Reflux - complications; Heartburn; Humans; Male; Medical equipment; Medical prognosis; Medical screening; Medical tests; Middle Aged; Oesophageal cancer; Patient satisfaction; Primary care; Primary Health Care; Study Protocol; Acid reflux; Oesophageal cancer; Biomarker; Cost effectiveness; Medical device; Endoscopy; Acceptability; Early detection; Heartburn; Quality of life