Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment

• Published in: Journal of neuroinflammation Vol. 15; no. 1; pp. 281 - 11
• Main Authors: Chiang, Pi-Ling, Chen, Hsiu-Ling, Lu, Cheng-Hsien, Chen, Yueh-Sheng, Chou, Kun-Hsien, Hsu, Tun-Wei, Chen, Meng-Hsiang, Tsai, Nai-Wen, Li, Shau-Hsuan, Lin, Wei-Che
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.09.2018; BioMed Central; BMC
• Subjects: Aged; Alzheimer's disease; Apoptosis; Atrophy; Brain mapping; Case-Control Studies; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cognitive ability; Correlation analysis; Dementia; Diagnosis; Dopamine; Female; Functional connectivity; Functional magnetic resonance imaging; Gray Matter - diagnostic imaging; Gray Matter - pathology; Gray matter volume; Health aspects; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Leukocytes - pathology; Lymphocyte apoptosis; Lymphocytes; Magnetic Resonance Imaging; Male; Mesial temporal network; Middle Aged; Movement disorders; Neural networks; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - diagnostic imaging; Neurodegenerative Diseases - etiology; Oxidative stress; Oxidative Stress - physiology; Oxygen - blood; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson Disease - pathology; Parkinson's disease; Peripheral blood; Prospective Studies; Psychological aspects; Retrospective Studies; Risk factors; Studies; Substantia grisea; Systemic oxidative stress; Temporal Lobe - diagnostic imaging; Temporal Lobe - pathology; Functional connectivity; Systemic oxidative stress; Mesial temporal network; Gray matter volume; Lymphocyte apoptosis; Parkinson’s disease; Cognitive impairment

To identify the vulnerable areas associated with systemic oxidative stress and further disruption of these vulnerable areas by measuring the associated morphology and functional network alterations in Parkinson's disease (PD) patients with and without cognitive impairment. This prospective stud...