The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

• Published in: Molecular cancer Vol. 14; no. 1; p. 184
• Main Authors: Raveh, Eli, Matouk, Imad J., Gilon, Michal, Hochberg, Abraham
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.11.2015; BioMed Central
• Subjects: Analysis; Animals; Carcinogenesis; Care and treatment; Cell cycle; Chromosomes; Disease Progression; Epithelial-Mesenchymal Transition - genetics; Epithelial-Mesenchymal Transition - physiology; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Genetic aspects; Genomic Instability - genetics; Humans; Hypoxia; Metabolism; Metastasis; Mutation; Proteins; Review; Risk factors; RNA, Long Noncoding - genetics; RNA, Long Noncoding - physiology; Stem cell research; Tumorigenesis

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data suggest that H19 is one of the major genes in can...