Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

• Published in: Journal of biomedical science Vol. 25; no. 1; pp. 46 - 14
• Main Authors: Cheng, Yuan-Ren, Jiang, Bo-Yang, Chen, Chih-Cheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2018; BioMed Central; BMC
• Subjects: Acid Sensing Ion Channels - metabolism; Acidification; Acidity; Acidosis; Acids; Amiloride; Animals; Arachidonic acid; ASIC; ASIC3; Blood pressure; Blood volume; Brain; Central nervous system; Channel gating; Chemoreception; Chemoreceptors; Degenerin; Detection; Extracellular matrix; Humans; Ion channels; Ion channels (ligand-gated); Ischemia; Ligands; Mechanoreceptors; Mechanotransduction; Mechanotransduction, Cellular - physiology; Membrane proteins; Mice; Muscle contraction; Muscles; Nerves; Nervous system; Neurons; Nociception - physiology; Nociceptor; Nociceptors; Pain; Pain perception; Physiological aspects; Physiology; Proprioception; Proprioception - physiology; Proprioceptors; Proteins; Rats; Review; Rodents; Sensory Receptor Cells - physiology; Sodium channels; Spinal cord; Tumors; ASIC; Nociceptor; Mechanotransduction; Pain; Proprioception; ASIC3

Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to...