A novel integrated care concept (NICC) versus standard care in the treatment of chronic cardiovascular diseases: protocol for the randomized controlled trial CardioCare MV

Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are benefici...

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Published inCurrent controlled trials in cardiovascular medicine Vol. 19; no. 1; p. 120
Main Authors Schmidt, Christian, Öner, Alper, Mann, Miriam, Krockenberger, Katja, Abbondanzieri, Melanie, Brandewiede, Bernard, Brüge, Armin, Hostenkamp, Gisela, Kaiser, Axel, Neumeyer, Henriette, Ziegler, Andreas
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Published England BioMed Central Ltd 20.02.2018
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Abstract Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients. The aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients. This study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention. DRKS, ID: DRKS00013124 . Registered on 5 October 2017; ClinicalTrials.gov , ID: NCT03317951. Registered on 17 October 2017.
AbstractList Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients. The aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients. This study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention.
Abstract Background Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients. Methods The aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients. Discussion This study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention. Trial registration DRKS, ID: DRKS00013124. Registered on 5 October 2017; ClinicalTrials.gov, ID: NCT03317951. Registered on 17 October 2017.
Background Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients. Methods The aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients. Discussion This study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention. Trial registration DRKS, ID: DRKS00013124. Registered on 5 October 2017; ClinicalTrials.gov, ID: NCT03317951. Registered on 17 October 2017. Keywords: Atrial fibrillation, Care center, Disease management program, Evidence-based care, Heart failure, Hospitalization, Integrated care, Randomized controlled trial, Telemedicine, Treatment-resistant hypertension
Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients. The aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients. This study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention. DRKS, ID: DRKS00013124 . Registered on 5 October 2017; ClinicalTrials.gov , ID: NCT03317951. Registered on 17 October 2017.
BackgroundCardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease management programs have been shown for patients with heart failure (HF). Remote monitoring and telemonitoring with active intervention are beneficial in atrial fibrillation (AF) and therapy-resistant hypertension (TRH), respectively. For these patients, we have developed a novel integrated care concept (NICC) which combines telemedicine with intensive support by a care center, including a call center, an integrated care network including inpatient and outpatient care providers and guideline therapy for patients.MethodsThe aim of the study is to demonstrate the superiority of NICC over guideline therapy alone. The trial is designed as open-label, bi-center, parallel-group design with two groups and a blinded observer. Patients will be included if they are either inpatients or if they are referred to the outpatient clinic of the hospitals by their treating physician. Randomization will be done individually with stratification by cardiovascular disease (AF, HF, TRH), center and admission type. Primary endpoints are based on the 1-year observation period after randomization. The first primary endpoint is the composite endpoint consisting of mortality, stroke and myocardial infarction. The number of hospitalizations form the second primary endpoint. The third primary endpoint is identical to the first primary endpoint plus cardiac decompensation. Adjustments for multiple testing are done using a fall-back strategy. Secondary endpoints include patient adherence, health care costs, quality of life, and safety. A sample size of 2930 gives 80% power at the two-sided 2.5% test level for the first primary endpoint. The power for the second primary endpoint is 99.8% at this sample size, and it is 80% with 1086 patients.DiscussionThis study will inform care providers whether quality of care can be improved by an integrated care concept providing telemedicine through a round-the-clock call center approach. We expect that cost of the NICC will be lower than standard care because of reduced hospitalizations. If the study has a positive result, NICC is planned to be immediately rolled out in the federal state of Mecklenburg-West Pomerania and other federal states in Germany. The trial will also guide additional research to disentangle the effects of this complex intervention.Trial registrationDRKS, ID: DRKS00013124. Registered on 5 October 2017;ClinicalTrials.gov, ID: NCT03317951. Registered on 17 October 2017.
ArticleNumber 120
Audience Academic
Author Abbondanzieri, Melanie
Brandewiede, Bernard
Krockenberger, Katja
Brüge, Armin
Ziegler, Andreas
Hostenkamp, Gisela
Kaiser, Axel
Öner, Alper
Neumeyer, Henriette
Mann, Miriam
Schmidt, Christian
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Cites_doi 10.1093/eurheartj/ehw210
10.1007/s00392-014-0799-7
10.1371/journal.pmed.1000251
10.1161/CIRCULATIONAHA.113.005119
10.1093/europace/eut114
10.1007/s40258-017-0310-5
10.1026/0012-1924.50.4.171
10.1161/HYPERTENSIONAHA.111.171520
10.1067/mhj.2003.54
10.1002/mpr.329
10.1185/030079906X167462
10.1161/CIRCULATIONAHA.110.940262
10.1097/HJH.0b013e32835ca8dd
10.1007/s00392-015-0841-4
10.1016/0168-8510(96)00822-6
10.1016/S0828-282X(09)70098-4
10.1056/NEJMsa0902321
10.1093/eurheartj/ehw128
10.1038/ajh.2011.100
10.1002/sim.4780080705
10.1159/000376585
10.1136/hrt.2002.008748
10.1016/S0140-6736(07)61835-2
10.1038/jhh.2014.73
10.1186/1471-2458-13-1027
10.1161/01.CIR.95.4.1085
10.1111/j.1475-6773.2005.00397.x
10.1177/2047487312450545
10.1111/j.1524-4733.2008.00416.x
10.1161/HYPERTENSIONAHA.116.08818
10.1093/eurheartj/ehr419
10.1097/MLR.0b013e318160d093
10.1136/hrt.2004.048389
10.1038/npjpcrm.2015.71
10.1001/jama.288.15.1909
10.7326/0003-4819-158-3-201302050-00583
10.1186/1471-2261-6-43
10.1513/AnnalsATS.201308-259RM
10.1002/ejhf.567
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Issue 1
Keywords Heart failure
Treatment-resistant hypertension
Integrated care
Telemedicine
Evidence-based care
Atrial fibrillation
Disease management program
Hospitalization
Care center
Randomized controlled trial
Language English
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PublicationCentury 2000
PublicationDate 2018-02-20
PublicationDateYYYYMMDD 2018-02-20
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  year: 2018
  text: 2018-02-20
  day: 20
PublicationDecade 2010
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PublicationTitle Current controlled trials in cardiovascular medicine
PublicationTitleAlternate Trials
PublicationYear 2018
Publisher BioMed Central Ltd
BioMed Central
BMC
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References N Werz (2502_CR5) 2013
R Holland (2502_CR16) 2005; 91
T Bodenheimer (2502_CR28) 2002; 288
A Ullrich (2502_CR44) 2010; 3
R Brooks (2502_CR37) 1996; 37
A Schuchert (2502_CR8) 2005; 56
2502_CR3
2502_CR1
KF Schulz (2502_CR32) 2010; 7
ML Pearson (2502_CR29) 2005; 40
2502_CR14
DE Wennberg (2502_CR17) 2010; 363
OS Indridason (2502_CR20) 2003; 145
FA McAlister (2502_CR15) 2004; 44
B Löwe (2502_CR40) 2002
S Stewart (2502_CR11) 2004; 90
RP Ricci (2502_CR21) 2013; 15
H Pinnock (2502_CR30) 2014; 11
S Omboni (2502_CR26) 2013; 31
MR Boland (2502_CR27) 2015; 25
P Ponikowski (2502_CR35) 2016; 2016
DJ Hyman (2502_CR23) 2015; 29
SS Chugh (2502_CR7) 2014; 129
AW Chan (2502_CR31) 2013; 158
S Hopewell (2502_CR33) 2008; 371
MI Ahmed (2502_CR13) 2011; 57
K Gräfe (2502_CR41) 2004; 50
DR Bristol (2502_CR47) 1989; 8
P Mabo (2502_CR22) 2012; 33
P Kirchhof (2502_CR34) 2016; 2016
MJ Taylor (2502_CR10) 2007; 23
JE Tarride (2502_CR2) 2009; 25
S Omboni (2502_CR25) 2011; 24
T Neumann (2502_CR12) 2009; 106
RL de Jager (2502_CR24) 2017; 69
N Oldridge (2502_CR39) 2014; 21
B Löwe (2502_CR42) 2008; 46
T Meinertz (2502_CR6) 2015; 104
CW Topp (2502_CR43) 2015; 84
DS Lee (2502_CR19) 2010; 122
M Christ (2502_CR48) 2016; 18
NH Miller (2502_CR4) 1997; 95
A Jovicic (2502_CR18) 2006; 6
NJ Devlin (2502_CR38) 2017; 15
MJ Azur (2502_CR46) 2011; 20
JM Zill (2502_CR45) 2013; 13
C Ohlmeier (2502_CR49) 2015; 104
D McBride (2502_CR9) 2009; 12
G Mancia (2502_CR36) 2013; 2013
References_xml – volume: 2016
  start-page: 2893
  issue: 37
  year: 2016
  ident: 2502_CR34
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehw210
  contributor:
    fullname: P Kirchhof
– volume: 104
  start-page: 112
  year: 2015
  ident: 2502_CR6
  publication-title: Clin Res Cardiol
  doi: 10.1007/s00392-014-0799-7
  contributor:
    fullname: T Meinertz
– volume: 7
  start-page: e1000251
  year: 2010
  ident: 2502_CR32
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000251
  contributor:
    fullname: KF Schulz
– volume: 129
  start-page: 837
  year: 2014
  ident: 2502_CR7
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.005119
  contributor:
    fullname: SS Chugh
– volume: 15
  start-page: i35
  issue: Suppl 1
  year: 2013
  ident: 2502_CR21
  publication-title: Europace
  doi: 10.1093/europace/eut114
  contributor:
    fullname: RP Ricci
– ident: 2502_CR14
– volume: 15
  start-page: 127
  year: 2017
  ident: 2502_CR38
  publication-title: Appl Health Econ Health Policy
  doi: 10.1007/s40258-017-0310-5
  contributor:
    fullname: NJ Devlin
– volume-title: Gesundheitsfragebogen für Patienten (PHQ-D). Komplettversion und Kurzform. Testmappe mit Manual, Fragebögen, Schablonen
  year: 2002
  ident: 2502_CR40
  contributor:
    fullname: B Löwe
– volume: 50
  start-page: 171
  year: 2004
  ident: 2502_CR41
  publication-title: Diagnostica
  doi: 10.1026/0012-1924.50.4.171
  contributor:
    fullname: K Gräfe
– volume: 106
  start-page: 269
  year: 2009
  ident: 2502_CR12
  publication-title: Dtsch Arztebl Int
  contributor:
    fullname: T Neumann
– volume: 57
  start-page: 1045
  year: 2011
  ident: 2502_CR13
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.171520
  contributor:
    fullname: MI Ahmed
– ident: 2502_CR1
– volume: 56
  start-page: 361
  year: 2005
  ident: 2502_CR8
  publication-title: Med Welt
  contributor:
    fullname: A Schuchert
– volume: 3
  start-page: 359
  year: 2010
  ident: 2502_CR44
  publication-title: Klin Diagn Eval
  contributor:
    fullname: A Ullrich
– volume: 145
  start-page: 300
  year: 2003
  ident: 2502_CR20
  publication-title: Am Heart J
  doi: 10.1067/mhj.2003.54
  contributor:
    fullname: OS Indridason
– volume: 20
  start-page: 40
  year: 2011
  ident: 2502_CR46
  publication-title: Int J Methods Psychiatr Res
  doi: 10.1002/mpr.329
  contributor:
    fullname: MJ Azur
– volume: 23
  start-page: 495
  year: 2007
  ident: 2502_CR10
  publication-title: Curr Med Res Opin
  doi: 10.1185/030079906X167462
  contributor:
    fullname: MJ Taylor
– volume: 44
  start-page: 810
  year: 2004
  ident: 2502_CR15
  publication-title: J Am Coll Cardiol
  contributor:
    fullname: FA McAlister
– volume: 122
  start-page: 1806
  year: 2010
  ident: 2502_CR19
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.110.940262
  contributor:
    fullname: DS Lee
– volume: 31
  start-page: 455
  year: 2013
  ident: 2502_CR26
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e32835ca8dd
  contributor:
    fullname: S Omboni
– volume: 104
  start-page: 688
  year: 2015
  ident: 2502_CR49
  publication-title: Clin Res Cardiol
  doi: 10.1007/s00392-015-0841-4
  contributor:
    fullname: C Ohlmeier
– volume: 37
  start-page: 53
  year: 1996
  ident: 2502_CR37
  publication-title: Health Policy
  doi: 10.1016/0168-8510(96)00822-6
  contributor:
    fullname: R Brooks
– volume: 25
  start-page: e195
  year: 2009
  ident: 2502_CR2
  publication-title: Can J Cardiol
  doi: 10.1016/S0828-282X(09)70098-4
  contributor:
    fullname: JE Tarride
– volume: 363
  start-page: 1245
  year: 2010
  ident: 2502_CR17
  publication-title: N Engl J Med
  doi: 10.1056/NEJMsa0902321
  contributor:
    fullname: DE Wennberg
– volume: 2016
  start-page: 2129
  issue: 37
  year: 2016
  ident: 2502_CR35
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehw128
  contributor:
    fullname: P Ponikowski
– volume: 24
  start-page: 989
  year: 2011
  ident: 2502_CR25
  publication-title: Am J Hypertens
  doi: 10.1038/ajh.2011.100
  contributor:
    fullname: S Omboni
– volume: 8
  start-page: 803
  year: 1989
  ident: 2502_CR47
  publication-title: Stat Med
  doi: 10.1002/sim.4780080705
  contributor:
    fullname: DR Bristol
– volume: 84
  start-page: 167
  year: 2015
  ident: 2502_CR43
  publication-title: Psychother Psychosom
  doi: 10.1159/000376585
  contributor:
    fullname: CW Topp
– ident: 2502_CR3
– volume: 90
  start-page: 286
  year: 2004
  ident: 2502_CR11
  publication-title: Heart
  doi: 10.1136/hrt.2002.008748
  contributor:
    fullname: S Stewart
– volume: 371
  start-page: 281
  year: 2008
  ident: 2502_CR33
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)61835-2
  contributor:
    fullname: S Hopewell
– volume: 29
  start-page: 213
  year: 2015
  ident: 2502_CR23
  publication-title: J Hum Hypertens
  doi: 10.1038/jhh.2014.73
  contributor:
    fullname: DJ Hyman
– volume: 13
  start-page: 1027
  year: 2013
  ident: 2502_CR45
  publication-title: BMC Public Health
  doi: 10.1186/1471-2458-13-1027
  contributor:
    fullname: JM Zill
– volume: 95
  start-page: 1085
  year: 1997
  ident: 2502_CR4
  publication-title: Circulation
  doi: 10.1161/01.CIR.95.4.1085
  contributor:
    fullname: NH Miller
– volume: 40
  start-page: 978
  year: 2005
  ident: 2502_CR29
  publication-title: Health Serv Res
  doi: 10.1111/j.1475-6773.2005.00397.x
  contributor:
    fullname: ML Pearson
– volume: 21
  start-page: 98
  year: 2014
  ident: 2502_CR39
  publication-title: Eur J Prev Cardiol
  doi: 10.1177/2047487312450545
  contributor:
    fullname: N Oldridge
– volume: 12
  start-page: 293
  year: 2009
  ident: 2502_CR9
  publication-title: Value Health
  doi: 10.1111/j.1524-4733.2008.00416.x
  contributor:
    fullname: D McBride
– volume: 69
  start-page: 678
  year: 2017
  ident: 2502_CR24
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.116.08818
  contributor:
    fullname: RL de Jager
– volume: 33
  start-page: 1105
  year: 2012
  ident: 2502_CR22
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehr419
  contributor:
    fullname: P Mabo
– start-page: 384
  volume-title: Handwörterbuch des politischen Systems der Bundesrepublik Deutschland
  year: 2013
  ident: 2502_CR5
  contributor:
    fullname: N Werz
– volume: 2013
  start-page: 2159
  issue: 34
  year: 2013
  ident: 2502_CR36
  publication-title: Eur Heart J
  contributor:
    fullname: G Mancia
– volume: 46
  start-page: 266
  year: 2008
  ident: 2502_CR42
  publication-title: Med Care
  doi: 10.1097/MLR.0b013e318160d093
  contributor:
    fullname: B Löwe
– volume: 91
  start-page: 899
  year: 2005
  ident: 2502_CR16
  publication-title: Heart
  doi: 10.1136/hrt.2004.048389
  contributor:
    fullname: R Holland
– volume: 25
  start-page: 15071
  year: 2015
  ident: 2502_CR27
  publication-title: NPJ Prim Care Respir Med
  doi: 10.1038/npjpcrm.2015.71
  contributor:
    fullname: MR Boland
– volume: 288
  start-page: 1909
  year: 2002
  ident: 2502_CR28
  publication-title: JAMA
  doi: 10.1001/jama.288.15.1909
  contributor:
    fullname: T Bodenheimer
– volume: 158
  start-page: 200
  year: 2013
  ident: 2502_CR31
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-158-3-201302050-00583
  contributor:
    fullname: AW Chan
– volume: 6
  start-page: 43
  year: 2006
  ident: 2502_CR18
  publication-title: BMC Cardiovasc Disord
  doi: 10.1186/1471-2261-6-43
  contributor:
    fullname: A Jovicic
– volume: 11
  start-page: S118
  issue: Suppl 2
  year: 2014
  ident: 2502_CR30
  publication-title: Ann Am Thorac Soc
  doi: 10.1513/AnnalsATS.201308-259RM
  contributor:
    fullname: H Pinnock
– volume: 18
  start-page: 1009
  year: 2016
  ident: 2502_CR48
  publication-title: Eur J Heart Fail
  doi: 10.1002/ejhf.567
  contributor:
    fullname: M Christ
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Snippet Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of disease...
Background Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of...
BackgroundCardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of...
BACKGROUNDCardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive effects of...
Abstract Background Cardiovascular diseases are the major cause of death globally and represent a major economic burden on health care systems. Positive...
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StartPage 120
SubjectTerms Activities of daily living
Analysis
Atrial fibrillation
Atrial Fibrillation - therapy
Cardiac arrhythmia
Cardiology
Cardiovascular diseases
Care and treatment
Care center
Chronic Disease
Clinical trials
Collaboration
Data Interpretation, Statistical
Delivery of Health Care, Integrated
Diagnosis
Disease management
Disease management program
Endpoint Determination
Evidence-based care
Family physicians
Health care costs
Health care expenditures
Heart attacks
Heart failure
Heart Failure - therapy
Hospitalization
Humans
Hypertension
Hypertension - therapy
Hypotheses
Integrated delivery systems
Intervention
Morbidity
Mortality
Multidisciplinary teams
Patient compliance
Prospective Studies
Randomized Controlled Trials as Topic
Registration
Research Design
Risk factors
Sample Size
Stroke
Study Protocol
Telemedicine
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Title A novel integrated care concept (NICC) versus standard care in the treatment of chronic cardiovascular diseases: protocol for the randomized controlled trial CardioCare MV
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