Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

• Published in: Journal of neuroinflammation Vol. 15; no. 1; pp. 251 - 12
• Main Authors: Martín-Hernández, David, Caso, Javier R., Javier Meana, J., Callado, Luis F., Madrigal, José L. M., García-Bueno, Borja, Leza, Juan C.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.09.2018; BioMed Central; BMC
• Subjects: Analysis of Variance; Annexin A2 - metabolism; Antidepressants; Antidepressive Agents - therapeutic use; Antioxidants; Antioxidants - metabolism; Autopsy; Brain; Brain research; Care and treatment; Chaperonin 60 - metabolism; Cortex (frontal); Cytokines; Depressive Disorder, Major - complications; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - pathology; DNA-Binding Proteins - metabolism; Dosage and administration; Enzymes; Frontal Lobe - drug effects; Frontal Lobe - metabolism; Frontal Lobe - pathology; Gene expression; Genetic aspects; Health aspects; Hsp60 protein; Hsp70 protein; Humans; Immune response; Immune system; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Innate immunity; Kinases; Legal medicine; Major depression; Major depressive disorder; Mental depression; Mitogen-activated protein kinases; Neuroinflammation; Neurosciences; Neurotransmitters; NF-kappa B - metabolism; Oxidative stress; p38 Mitogen-Activated Protein Kinases - metabolism; Pathogenesis; Postmortem frontal cortex; Prefrontal cortex; Protein transport; Proteins; Psychiatry; Rodents; S100 Proteins - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; Studies; Toll-Like Receptor 4 - metabolism; Toll-like receptor 4 pathway; Toll-like receptors; Transcription factors; Transcription Factors - metabolism; Toll-like receptor 4 pathway; Antidepressants; Major depression; Nrf2 pathway; Postmortem frontal cortex; Neuroinflammation; Mitogen-activated protein kinases

Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the brain of patients with MDD has been elusive. This work explores whether the protein expressi...