URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion - Su, Shao-Hua; Wu, Yi-Fang; Lin, Qi; Wang, Da-Peng; Hai, Jian (Journal of neuroinflammation, 2019)
Keywords: Acetylcysteine; Animals; Apoptosis; Autophagy; Autophagy - drug effects; Autophagy - physiology; Benzamides - pharmacology; Benzamides - therapeutic use; BNIP3 protein; Brain; Brain injury; Brain Ischemia - metabolism; Brain Ischemia - prevention & control; Brain research; Carbamates - pharmacology; Carbamates - therapeutic use; Carotid arteries; Carotid artery; Cerebral blood flow; Chloroquine; Chronic cerebral hypoperfusion; Cyclooxygenase-2; Cytokines; Disease Models, Animal; Electron microscopy; Enzyme-linked immunosorbent assay; Fluorescent antibody technique; Health aspects; Hippocampus - drug effects; Hippocampus - metabolism; IL-1β; Immunofluorescence; Inflammasomes; Inflammasomes - antagonists & inhibitors; Inflammasomes - metabolism; Inflammation; Ischemia; Laboratory animals; Male; Microscopy; Minocycline; Mitochondria; Mitophagy; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Nitric-oxide synthase; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; Oligomerization; Oligomers; Parkin protein; Phagocytosis; Proteins; Pyrin protein; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Rodents; ROS; Tumor necrosis factor-α; Type 2 diabetes; Veins & arteries; Western blotting; United States--US; Chronic cerebral hypoperfusion; Mitophagy; NLRP3 inflammasome; Autophagy; ROS