Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 1; p. 303
• Main Authors: Baev, Dmitry S., Blokhin, Mikhail E., Chirkova, Varvara Yu, Belenkaya, Svetlana V., Luzina, Olga A., Yarovaya, Olga I., Salakhutdinov, Nariman F., Shcherbakov, Dmitry N.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.12.2022; MDPI
• Subjects: Amides - metabolism; Amides - pharmacology; Amino acids; antiviral; Antiviral agents; Antiviral Agents - chemistry; Antiviral drugs; Coronaviruses; COVID-19; Dosage and administration; Enzymes; FRET; Humans; main protease; Molecular Docking Simulation; molecular modeling; Phenols; Protease Inhibitors - chemistry; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; triterpene amide; Viruses; Russia; SARS-CoV-2; FRET; main protease; molecular modeling; antiviral; triterpene amide

Although the incidence and mortality of SARS-CoV-2 infection has been declining during the pandemic, the problem related to designing novel antiviral drugs that could effectively resist viruses in the future remains relevant. As part of our continued search for chemical compounds that are capable of...