Decreased microbiome diversity in the HIV small airway epithelium

• Published in: Respiratory research Vol. 19; no. 1; pp. 140 - 8
• Main Authors: Xu, Stella, Tsai, Amy, Sze, Marc A., Vucic, Emily A., Shaipanich, Tawimas, Harris, Marianne, Guillemi, Silvia, Yang, Julia, Sinha, Sunita, Nislow, Corey, Montaner, Julio, Lam, Wan, Lam, Stephen, Sin, Don D., Paul Man, S. F., Leung, Janice M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.07.2018; BioMed Central; BMC
• Subjects: Abundance; Antibiotics; Bacteroidetes; Campylobacter; Chronic obstructive pulmonary disease; Community composition; Control; COPD; Cystic fibrosis; Deoxyribonucleic acid; DNA; Epithelium; Firmicutes; Gene expression; HIV; HIV infections; Human immunodeficiency virus; Immunosuppression; Lung diseases; Medical screening; Microbiome; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Obstructive lung disease; Pathogenesis; Proteobacteria; Relative abundance; Respiratory tract; rRNA 16S; Smoking; Viruses; HIV; Epithelium; COPD; Microbiome

Persons living with human immunodeficiency virus (PLWH) face an increased burden of chronic obstructive pulmonary disease (COPD). Repeated pulmonary infections, antibiotic exposures, and immunosuppression may contribute to an altered small airway epithelium (SAE) microbiome. SAE cells were collected...