Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

• Published in: Molecular cancer Vol. 17; no. 1; p. 171
• Main Authors: Bagger, Sofie Otzen, Hopkinson, Branden Michael, Pandey, Deo Prakash, Bak, Mads, Brydholm, Andreas Vincent, Villadsen, Rene, Helin, Kristian, Rønnov-Jessen, Lone, Petersen, Ole William, Kim, Jiyoung
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.12.2018; BioMed Central; BMC
• Subjects: Biology; Breast cancer; Cancer cells; Cancer screening; Carcinogenesis; Cellular signal transduction; Cloning; Collective migration; Diagnosis; Genetic aspects; Letter to the Editor; Lungs; Medical prognosis; Mesenchyme; Metastasis; Non-EMT; p53 Protein; shRNA screening; Stem cells; Survival analysis; Tumorigenesis; Ubiquitin; Ubiquitin-protein ligase; Denmark; shRNA screening; Collective migration; Breast cancer; Non-EMT

Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somew...