New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis

• Published in: Frontiers in Immunology Vol. 12; p. 709178
• Main Authors: Cheng, Liyun, Wang, Yanyan, Wu, Ruihe, Ding, Tingting, Xue, Hongwei, Gao, Chong, Li, Xiaofeng, Wang, Caihong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 19.07.2021; Frontiers Media S.A
• Subjects: Arthritis, Rheumatoid; Arthritis, Rheumatoid - pathology; biomarkers; Fibroblasts; Fibroblasts - classification; Fibroblasts - physiology; Humans; Immunologic diseases. Allergy; Immunology; Macrophages; Macrophages - physiology; RC581-607; rheumatoid arthritis; Sequence Analysis, RNA; Sequence Analysis, RNA - methods; Single-Cell Analysis; Single-Cell Analysis - methods; single-cell RNA sequencing; synovial fibroblast; synovial macrophage; Synovial Membrane; Synovial Membrane - cytology; single-cell RNA sequencing; synovial macrophage; synovial fibroblast; rheumatoid arthritis; biomarkers

Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathologic...