New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis

Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathologic...

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Published inFrontiers in Immunology Vol. 12; p. 709178
Main Authors Cheng, Liyun, Wang, Yanyan, Wu, Ruihe, Ding, Tingting, Xue, Hongwei, Gao, Chong, Li, Xiaofeng, Wang, Caihong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media SA 19.07.2021
Frontiers Media S.A
Subjects
Arthritis, Rheumatoid
Arthritis, Rheumatoid - pathology
biomarkers
Fibroblasts
Fibroblasts - classification
Fibroblasts - physiology
Humans
Immunologic diseases. Allergy
Immunology
Macrophages
Macrophages - physiology
RC581-607
rheumatoid arthritis
Sequence Analysis, RNA
Sequence Analysis, RNA - methods
Single-Cell Analysis
Single-Cell Analysis - methods
single-cell RNA sequencing
synovial fibroblast
synovial macrophage
Synovial Membrane
Synovial Membrane - cytology
single-cell RNA sequencing
synovial macrophage
synovial fibroblast
rheumatoid arthritis
biomarkers
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Abstract Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.
AbstractList Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.
Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.
Author Liyun Cheng
Ruihe Wu
Caihong Wang
Xiaofeng Li
Yanyan Wang
H. Xue
Tingting Ding
Chong Gao
AuthorAffiliation 1 Department of Rheumatology, the Second Hospital of Shanxi Medical University , Taiyuan , China
2 Pathology, Joint Program in Transfusion Medicine, Brigham and Women’s Hospital/Children’s Hospital, Harvard Medical School , Boston, MA , United States
AuthorAffiliation_xml – name: 1 Department of Rheumatology, the Second Hospital of Shanxi Medical University , Taiyuan , China
– name: 2 Pathology, Joint Program in Transfusion Medicine, Brigham and Women’s Hospital/Children’s Hospital, Harvard Medical School , Boston, MA , United States
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Copyright Copyright © 2021 Cheng, Wang, Wu, Ding, Xue, Gao, Li and Wang.
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Keywords single-cell RNA sequencing
synovial macrophage
synovial fibroblast
rheumatoid arthritis
biomarkers
Language English
License Copyright © 2021 Cheng, Wang, Wu, Ding, Xue, Gao, Li and Wang.
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Reviewed by: Nan Mu, Fourth Military Medical University, China; Rowan Hardy, University of Birmingham, United Kingdom
Edited by: Shemin Lu, Xi’an Jiaotong University, China
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
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Snippet Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level,...
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SubjectTerms Arthritis, Rheumatoid
Arthritis, Rheumatoid - pathology
biomarkers
Fibroblasts
Fibroblasts - classification
Fibroblasts - physiology
Humans
Immunologic diseases. Allergy
Immunology
Macrophages
Macrophages - physiology
RC581-607
rheumatoid arthritis
Sequence Analysis, RNA
Sequence Analysis, RNA - methods
Single-Cell Analysis
Single-Cell Analysis - methods
single-cell RNA sequencing
synovial fibroblast
synovial macrophage
Synovial Membrane
Synovial Membrane - cytology
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Title New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis
URI https://cir.nii.ac.jp/crid/1873680965970131328
https://www.ncbi.nlm.nih.gov/pubmed/34349767
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https://pubmed.ncbi.nlm.nih.gov/PMC8326910
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Volume 12
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