Repeated intravitreal injections of antivascular endothelial growth factor in patients with neovascular age-related macular degeneration may increase the risk of ischemic optic neuropathy

• Published in: BMC ophthalmology Vol. 19; no. 1; pp. 268 - 7
• Main Authors: Chen, Yu-Yen, Chou, Pesus, Huang, Yu-Fang, Chien, Hung-Jen, Wu, Yu-Chieh, Lee, Chia-Chi, Huang, Li-Ying, Chen, Hsin-Hua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.12.2019; BioMed Central; BMC
• Subjects: Age; Aged; Aged, 80 and over; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - adverse effects; Antivascular endothelial growth factor; Cardiovascular disease; Care and treatment; Case reports; Choroidal Neovascularization - diagnosis; Choroidal Neovascularization - drug therapy; Cohort analysis; Cohort study; Comorbidity; Coronary artery disease; Databases, Factual; Diabetes; Diabetes mellitus; Diabetic neuropathy; Edema; Endothelial growth factors; Female; Fluorescein Angiography; Glaucoma; Health; Heart diseases; Humans; Hyperlipidemia; Hypertension; Injection; Insurance; Intravitreal injection; Intravitreal Injections; Ischemia; Ischemic optic neuropathy; Macular degeneration; Male; Medical research; Middle Aged; Myocardial ischemia; National health insurance; National Health Programs; Neovascular age-related macular degeneration; Online databases; Ophthalmology; Optic neuropathy; Optic Neuropathy, Ischemic - chemically induced; Optic Neuropathy, Ischemic - diagnosis; Physiological aspects; Retreatment; Retrospective Studies; Risk factor; Risk Factors; Taiwan; Tomography, Optical Coherence; Variables; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Wet Macular Degeneration - diagnosis; Wet Macular Degeneration - drug therapy; Taiwan; National Health Insurance Research Database; Ischemic optic neuropathy; Intravitreal injection; Cohort study; Neovascular age-related macular degeneration; Risk factor; Antivascular endothelial growth factor

Previous case reports have demonstrated the occurrence of ischemic optic neuropathy (ION) following intravitreal injections of antivascular endothelial growth factor (anti-VEGF). However, no previous studies have investigated the impact of injection numbers on the risk of ION. The aim of our study w...