Tumor microenvironment participates in metastasis of pancreatic cancer

• Published in: Molecular cancer Vol. 17; no. 1; pp. 108 - 15
• Main Authors: Ren, Bo, Cui, Ming, Yang, Gang, Wang, Huanyu, Feng, Mengyu, You, Lei, Zhao, Yupei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.07.2018; BioMed Central; BMC
• Subjects: Angiogenesis; Animals; Biomarkers, Tumor - metabolism; Cancer; Cancer therapies; Care and treatment; Cell growth; Chemotherapy; Desmoplasia; Diagnosis; Disease Progression; DNA methylation; Drug therapy, Combination; Epithelial-Mesenchymal Transition; Growth factors; Humans; Hypoxia; Immunosuppression; Immunotherapy; Medical prognosis; Mesenchyme; Metastases; Metastasis; Mortality; Mutation; Neoplasm Metastasis; Neutrophils; Pancreatic cancer; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Prognosis; Radiation therapy; Review; Stromal cells; Tumor Microenvironment; Tumors; Immunosuppression; Desmoplasia; Metastasis; Tumor microenvironment; Pancreatic cancer

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated i...