Tumor microenvironment participates in metastasis of pancreatic cancer

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated i...

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Published inMolecular cancer Vol. 17; no. 1; pp. 108 - 15
Main Authors Ren, Bo, Cui, Ming, Yang, Gang, Wang, Huanyu, Feng, Mengyu, You, Lei, Zhao, Yupei
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 30.07.2018
BioMed Central
BMC
Subjects
Angiogenesis
Animals
Biomarkers, Tumor - metabolism
Cancer
Cancer therapies
Care and treatment
Cell growth
Chemotherapy
Desmoplasia
Diagnosis
Disease Progression
DNA methylation
Drug therapy, Combination
Epithelial-Mesenchymal Transition
Growth factors
Humans
Hypoxia
Immunosuppression
Immunotherapy
Medical prognosis
Mesenchyme
Metastases
Metastasis
Mortality
Mutation
Neoplasm Metastasis
Neutrophils
Pancreatic cancer
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Prognosis
Radiation therapy
Review
Stromal cells
Tumor Microenvironment
Tumors
Immunosuppression
Desmoplasia
Metastasis
Tumor microenvironment
Pancreatic cancer
Online AccessGet full text

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Abstract Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival.
AbstractList Abstract Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival.
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival.
Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival.Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells and stromal cells is critical for pancreatic cancer progression and has been implicated in the failure of chemotherapy, radiation therapy and immunotherapy. Microenvironment formation requires interactions between pancreatic cancer cells and stromal cells. Components of the pancreatic cancer microenvironment that contribute to desmoplasia and immunosuppression are associated with poor patient prognosis. These components can facilitate desmoplasia and immunosuppression in primary and metastatic sites or can promote metastasis by stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, and pre-metastatic niche formation. Some molecules participate in both microenvironment formation and metastasis. In this review, we focus on the mechanisms of pancreatic cancer microenvironment formation and discuss how the pancreatic cancer microenvironment participates in metastasis, representing a potential target for combination therapy to enhance overall survival.
ArticleNumber 108
Audience Academic
Author Feng, Mengyu
You, Lei
Ren, Bo
Wang, Huanyu
Yang, Gang
Cui, Ming
Zhao, Yupei
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  givenname: Lei
  surname: You
  fullname: You, Lei
– sequence: 7
  givenname: Yupei
  surname: Zhao
  fullname: Zhao, Yupei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30060755$$D View this record in MEDLINE/PubMed
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Keywords Immunosuppression
Desmoplasia
Metastasis
Tumor microenvironment
Pancreatic cancer
Language English
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Snippet Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by...
Abstract Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment...
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StartPage 108
SubjectTerms Angiogenesis
Animals
Biomarkers, Tumor - metabolism
Cancer
Cancer therapies
Care and treatment
Cell growth
Chemotherapy
Desmoplasia
Diagnosis
Disease Progression
DNA methylation
Drug therapy, Combination
Epithelial-Mesenchymal Transition
Growth factors
Humans
Hypoxia
Immunosuppression
Immunotherapy
Medical prognosis
Mesenchyme
Metastases
Metastasis
Mortality
Mutation
Neoplasm Metastasis
Neutrophils
Pancreatic cancer
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Prognosis
Radiation therapy
Review
Stromal cells
Tumor Microenvironment
Tumors
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Title Tumor microenvironment participates in metastasis of pancreatic cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/30060755
https://www.proquest.com/docview/2089837168
https://www.proquest.com/docview/2080857502
https://pubmed.ncbi.nlm.nih.gov/PMC6065152
https://doaj.org/article/5d7f53384797417b93dcdec198e16f30
Volume 17
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