Association between elevated blood glucose level and non-valvular atrial fibrillation: a report from the Guangzhou heart study

• Published in: BMC cardiovascular disorders Vol. 19; no. 1; pp. 270 - 8
• Main Authors: Fu, Lu, Deng, Hai, Lin, Wei-dong, He, Shang-fei, Liu, Fang-zhou, Liu, Yang, Zhan, Xian-zhang, Fang, Xian-hong, Liao, Hong-tao, Wei, Wei, Liao, Zi-li, Tang, Li-hong, Fu, Zu-yi, Zheng, Mu-rui, Wu, Shu-lin, Xue, Yu-mei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.11.2019; BioMed Central; BMC
• Subjects: Adult; Age; Age Factors; Aged; Alcohol; Analysis; Atrial fibrillation; Atrial Fibrillation - diagnosis; Atrial Fibrillation - epidemiology; Biomarkers - blood; Blood glucose; Blood Glucose - analysis; Blood pressure; Blood tests; Cardiac arrhythmia; Cardiovascular disease; China - epidemiology; Cholesterol; Chronic obstructive pulmonary disease; Cities and towns; Cross-Sectional Studies; Data collection; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; EKG; Electrocardiography; Fasting; Female; Fibrillation; Glucose; Glucose Intolerance - blood; Glucose Intolerance - diagnosis; Glucose Intolerance - epidemiology; Health risk assessment; Heart; Heart attacks; Humans; Hyperglycemia; Hypertension; Hyperthyroidism; Impaired fasting glucose; Kidney diseases; Male; Males; Metabolic disorders; Middle Aged; Non-valvular atrial fibrillation; Population; Population studies; Prevalence; Prognosis; Questionnaires; Regression analysis; Risk Assessment; Risk Factors; Rural areas; Sex; Sex Factors; Substance abuse treatment; Time Factors; Type 2 diabetes; Type 2 diabetes mellitus; Up-Regulation; Womens health; China; Guangzhou China; Hyperglycemia; Impaired fasting glucose; Type 2 diabetes mellitus; Non-valvular atrial fibrillation; Sex
• DOI: 10.1186/s12872-019-1253-6
• ISSN: 1471-2261

To estimate the prevalence of elevated blood glucose level (EBG, including type 2 diabetes mellitus and impaired fasting glucose), and its association with non-valvular atrial fibrillation (NVAF) in Guangzhou, China. The population-based follow-up Guangzhou Heart Study collected baseline data from July 2015 to August 2017 among 12,013 permanent residents aged > 35 from 4 Guangzhou districts. Two streets (Dadong and Baiyun) in the Yuexiu District, and one street (Xiaoguwei) and two towns (Xinzao and Nancun) in the Panyu District were chosen as representative of urban and rural areas, respectively. Each participant completed a comprehensive questionnaire, and underwent physical examination, blood sample collection for laboratory testing, electrocardiography, and other evaluations. Multivariable logistic regression analyses were used to estimate the independent association between hyperglycemia and NVAF prevalence. The prevalence of EBG in overall study population was 29.9%. Compared with residents without EBG, the odds ratio (OR) for AF among residents with EBG was significantly higher (1.94, 95% confidence interval [CI]: 1.40-2.70, P <  0.001), even after multivariate adjustment for metabolic abnormalities (OR = 1.60, 95% CI: 1.14-2.25, P = 0.007), and driven by women (OR = 1.80, 95% CI: 1.12-2.91, P = 0.016). In Guangzhou, China, prevalence of EBG is high among residents aged > 35 years and associated with a multivariate adjusted increase in prevalence of NVAF overall and in women.