FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells

• Published in: BMC cardiovascular disorders Vol. 15; no. 1; p. 80
• Main Authors: Li, En, Wang, Ting, Wang, Feng, Wang, Tao, Sun, Li-qiang, Li, Li, Niu, Shao-hui, Zhang, Jin-ying
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.07.2015; BioMed Central
• Subjects: Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Atherosclerosis; Cholesterol; Fibroblast Growth Factors - pharmacology; Foam Cells - drug effects; Foam Cells - metabolism; Gene Expression Regulation; Humans; Lipids; Lipoproteins, LDL - toxicity; Macrophages - drug effects; Macrophages - metabolism; Manufacturing cells; Proteins; Transcription Factor CHOP - antagonists & inhibitors; Transcription Factor CHOP - biosynthesis
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-015-0077-2

FGF21,as a member of the fibroblast growth factor superfamily, is an important endogenous regulator to systemic glucose and lipid metabolism. Elevated serum FGF21 levels have been reported in subjects with coronary heart disease and carotid artery plaques. The formation and apoptosis of foam cell, i...