Immunological and morphological analysis of heterotopic ossification differs to healthy controls

• Published in: BMC musculoskeletal disorders Vol. 19; no. 1; pp. 327 - 7
• Main Authors: Trieb, Klemens, Meryk, Andreas, Senck, Sascha, Naismith, Erin, Grubeck-Loebenstein, Beatrix
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.09.2018; BioMed Central; BMC
• Subjects: Adult; Aged; Anisotropy; Arthroplasty (hip); Biomarkers - analysis; Bone and Bones - diagnostic imaging; Bone and Bones - immunology; Bone and Bones - pathology; Bone and Bones - surgery; Bone Density; Bone growth; Bone marrow; Bone strength; Cancellous bone; Case-Control Studies; CD34 antigen; Collagen; Collagenase; Computed tomography; Data processing; Female; Flow Cytometry; Fluorescent Antibody Technique; Fractures; Hip; Humans; Immune system; Immunofluorescence; Immunology; Isometric; Joint surgery; Lamellar bone; Leukocytes (granulocytic); Lymphocytes B; Lymphocytes T; Male; Middle Aged; Monocytes; Morphology; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - immunology; Muscle, Skeletal - pathology; Muscle, Skeletal - surgery; Musculoskeletal diseases; Musculoskeletal system; Ossification; Ossification (ectopic); Ossification, Heterotopic - diagnostic imaging; Ossification, Heterotopic - immunology; Ossification, Heterotopic - pathology; Ossification, Heterotopic - surgery; Patients; Phenotype; Progenitor cells; Spinal cord; Stem cells; Stroma; Trauma; Traumatic brain injury; X-Ray Microtomography; X-ray tubes

Formation of lamellar bone in non-osseus tissue is a pathological process called heterotopic ossification. It is the aim of this study to analyse the morphology and immunological status of patients with heterotopic ossification compared to individual healthy persons. Human bone marrow and blood samp...