A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome b...
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| Published in | PloS one Vol. 10; no. 9; p. e0138646 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
25.09.2015
Public Library of Science (PLoS) |
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| Abstract | Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.
Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.
In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.
Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.
ClinicalTrials.gov NCT01530685. |
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| AbstractList | BackgroundPreventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.ObjectivesOur aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.MethodsIn a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m2, unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.ResultsFour-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.ConclusionsFour-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed. Methods In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m2, unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization. Results Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement. Conclusions Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. Trial Registration ClinicalTrials.gov NCT01530685 Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed. In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization. Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement. Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. ClinicalTrials.gov NCT01530685. Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.BACKGROUNDPreventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.OBJECTIVESOur aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.METHODSIn a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.RESULTSFour-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.CONCLUSIONSFour-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.ClinicalTrials.gov NCT01530685.TRIAL REGISTRATIONClinicalTrials.gov NCT01530685. Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.ClinicalTrials.gov NCT01530685. Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed. Methods In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m 2 , unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization. Results Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement. Conclusions Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. Trial Registration ClinicalTrials.gov NCT01530685 |
| Author | Vatier, Camille Liu, Yuejun Bastard, Jean-Philippe Cotillard, Aurélie Guilbot, Angèle Allatif, Omran Clément, Karine Stévant, Marie Bieuvelet, Séverine Rizkalla, Salwa W. Langlois, Clotilde Fellahi, Soraya Brochot, Amandine |
| AuthorAffiliation | 3 Sorbonne University, Pierre and Marie Curie University, Paris 06, UMR_S 1166 I, Nutriomics Team, Paris, France 1 Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique—Hôpitaux de Paris, Heart and Nutrition Department, Pitié-Salpêtrière Hospital, and Human Nutrition Research Center—Ile de France, 75013, Paris, France 4 Assistance Publique-Hôpitaux de Paris, Biochemistry and Hormonology Department, Tenon Hospital, 75970, Paris, France 5 AdipoPhYt, 75013, Paris, France 6 Groupe PiLeJe, 75015, Paris, France Indiana University Richard M. Fairbanks School of Public Health, UNITED STATES 2 INSERM, UMR S U1166, Nutriomics, 75013, Paris, France |
| AuthorAffiliation_xml | – name: 6 Groupe PiLeJe, 75015, Paris, France – name: 1 Institute of Cardiometabolism and Nutrition, ICAN, Assistance Publique—Hôpitaux de Paris, Heart and Nutrition Department, Pitié-Salpêtrière Hospital, and Human Nutrition Research Center—Ile de France, 75013, Paris, France – name: 4 Assistance Publique-Hôpitaux de Paris, Biochemistry and Hormonology Department, Tenon Hospital, 75970, Paris, France – name: 5 AdipoPhYt, 75013, Paris, France – name: 2 INSERM, UMR S U1166, Nutriomics, 75013, Paris, France – name: 3 Sorbonne University, Pierre and Marie Curie University, Paris 06, UMR_S 1166 I, Nutriomics Team, Paris, France – name: Indiana University Richard M. Fairbanks School of Public Health, UNITED STATES |
| Author_xml | – sequence: 1 givenname: Yuejun surname: Liu fullname: Liu, Yuejun – sequence: 2 givenname: Aurélie surname: Cotillard fullname: Cotillard, Aurélie – sequence: 3 givenname: Camille surname: Vatier fullname: Vatier, Camille – sequence: 4 givenname: Jean-Philippe surname: Bastard fullname: Bastard, Jean-Philippe – sequence: 5 givenname: Soraya surname: Fellahi fullname: Fellahi, Soraya – sequence: 6 givenname: Marie surname: Stévant fullname: Stévant, Marie – sequence: 7 givenname: Omran surname: Allatif fullname: Allatif, Omran – sequence: 8 givenname: Clotilde surname: Langlois fullname: Langlois, Clotilde – sequence: 9 givenname: Séverine surname: Bieuvelet fullname: Bieuvelet, Séverine – sequence: 10 givenname: Amandine surname: Brochot fullname: Brochot, Amandine – sequence: 11 givenname: Angèle surname: Guilbot fullname: Guilbot, Angèle – sequence: 12 givenname: Karine surname: Clément fullname: Clément, Karine – sequence: 13 givenname: Salwa W. surname: Rizkalla fullname: Rizkalla, Salwa W. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26406981$$D View this record in MEDLINE/PubMed https://hal.sorbonne-universite.fr/hal-01275919$$DView record in HAL |
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| Copyright | 2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution 2015 Liu et al 2015 Liu et al |
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| DOI | 10.1371/journal.pone.0138646 |
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| License | Attribution: http://creativecommons.org/licenses/by This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Current address: INSERM, UMR_S938, Centre de Recherche Saint-Antoine, F-75012, Paris, France Conceived and designed the experiments: KC SWR SB. Performed the experiments: SWR YL CV. Analyzed the data: AC YL OA. Contributed reagents/materials/analysis tools: SF JPB MS. Wrote the paper: SWR YL KC. Formulation of the test product: CL. Represented the study sponsor and participated in study management: AG SB AB. Contributed to critical revision of the manuscript for important intellectual content and approved the final manuscript: SWR YL AC CV JPB SF MS OA CL SB AB AG KC. Had final responsibility for the decision to publish the findings: SWR YL AC CV JPB SF MS OA CL SB AB AG KC. Competing Interests: PileJe (Saint-Laurent-des-Autels, France) provided funding towards this study. SB, AG and CL are employed by PiLeJe; AC received a grant from PiLeJe, OA and YL received fees for data management and other study procedures on the behalf of PiLeJe, MS is employed by AdipoPhYt at the time of the study. There are no patents or products in development to declare. The tested product was marketed before the beginning of the study. Other: CV has received consultancy fees from AstraZeneca and Sanofi, support for travel and congress inscription from Novonordisk and Sanofi, and research materials from AstraZeneca; JPB has received speaker fees from the European Group for the Study of Insulin Resistance (EGIR) and from Servier and a research grant from the Association Nationale de la Recherche sur le SIDA (ANRS); SF has received support for congress attendance from Beckman Coulter; the other authors declare no conflict of interest. The above declarations have no effect on the authors' adherence to all the PLOS ONE policies on sharing data and materials. |
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| Snippet | Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.
Our aim was to evaluate the effects of 4-month treatment with a... Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of... Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.BACKGROUNDPreventing or slowing the progression of prediabetes to... BackgroundPreventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.ObjectivesOur aim was to evaluate the effects of... Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.Our aim was to evaluate the effects of 4-month treatment with a... Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of... |
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| SubjectTerms | Adipose tissue Adult Aged Blindness Blood Glucose - drug effects Blood Glucose - metabolism Body Composition - drug effects Body mass Body mass index Body size Body weight Carnosine Carnosine - administration & dosage Change detection Chromium Chromium - administration & dosage Cinnamomum zeylanicum - chemistry Cinnamon Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - prevention & control Diet Dietary Supplements Double-Blind Method Fasting Fasting - blood Fat-free body mass Female Glucose Hemoglobin Homeostasis Human health and pathology Humans Inflammation Insulin Insulin resistance Life assessment Life Sciences Lipids Male Markers Middle Aged Muscles - anatomy & histology Muscles - drug effects Muscles - metabolism Obesity Obesity - complications Obesity - diet therapy Overweight Overweight - complications Overweight - diet therapy Physical activity Placebos Plant Extracts - administration & dosage Prediabetic State - complications Prediabetic State - diet therapy Randomization Systematic review |
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| Title | A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26406981 https://www.proquest.com/docview/1719319356 https://www.proquest.com/docview/1718077798 https://hal.sorbonne-universite.fr/hal-01275919 https://pubmed.ncbi.nlm.nih.gov/PMC4583280 https://doaj.org/article/c376f430ba2a4a44aa411c81d3c085b4 http://dx.doi.org/10.1371/journal.pone.0138646 |
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