Characteristics and potentials of stem cells derived from human degenerated nucleus pulposus: potential for regeneration of the intervertebral disc

• Published in: BMC musculoskeletal disorders Vol. 18; no. 1; pp. 242 - 11
• Main Authors: Li, Xiao-Chuan, Tang, Yong, Wu, Jian-Hong, Yang, Pu-Shan, Wang, De-Li, Ruan, Di-Ke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.06.2017; BioMed Central; BMC
• Subjects: Adipocytes; Back pain; Biological characteristics; Bone marrow; Care and treatment; Cell cycle; Cell Differentiation - physiology; Cell growth; Cell nucleus; Cell proliferation; Cell therapy; Cells, Cultured; Chondrocytes; Chondrogenesis; Degeneration; Endogenous repair; Female; Flow cytometry; Gene expression; Homeostasis; Humans; Intervertebral disc; Intervertebral Disc - pathology; Intervertebral Disc - physiology; Intervertebral Disc Degeneration - pathology; Intervertebral discs; Intervertebral disk displacement; Male; Mesenchymal Stem Cells - physiology; Mesenchyme; Middle Aged; Musculoskeletal diseases; Nuclei; Nucleus pulposus; Nucleus Pulposus - pathology; Nucleus Pulposus - physiology; Nucleus Pulposus - transplantation; Nucleus pulposus derived stem cells; Osteoblasts; Patients; Penicillin; Regeneration - physiology; Regenerative medicine; Stem cells; Stem Cells - pathology; Stem Cells - physiology; Tissue engineering; Umbilical cord; Cell therapy; Biological characteristics; Intervertebral disc; Endogenous repair; Nucleus pulposus derived stem cells

Eliminating the symptoms during treatment of intervertebral disc degeneration (IVDD) is only a temporary solution that does not cure the underlying cause. A biological method to treat this disorder may be possible by the newly discovered nucleus pulposus derived stem cells (NPDCs). However, the unce...