IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study - Al-Soudi, A.; Doorenspleet, M. E.; Esveldt, R. E.; Burgemeister, L. T.; Hak, A. E.; van den Born, B. J. H.; Tas, S. W.; van Vollenhoven, R. F.; Klarenbeek, P. L.; de Vries, N. (Arthritis research & therapy, 2019)
Keywords: Adult; Aged; Antibodies, Antineutrophil Cytoplasmic - blood; Antibodies, Antineutrophil Cytoplasmic - immunology; Antigens; Arthritis; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biomarkers; Biomarkers - blood; Care and treatment; Cloning; Cross-Sectional Studies; Diagnosis; Diagnosis, Differential; Disease activity; Female; Granulomatosis with polyangiitis; Granulomatosis with Polyangiitis - diagnosis; Granulomatosis with Polyangiitis - genetics; Granulomatosis with Polyangiitis - immunology; Humans; Immunoglobulin G - blood; Immunoglobulin G - genetics; Immunoglobulin G - immunology; Immunoglobulin G4; Immunoglobulins; Inflammatory diseases; Longitudinal Studies; Male; Middle Aged; Mortality; Myeloblastin - immunology; Myeloblastin - metabolism; Neutrophils; Observational studies; Pathogenesis; Patients; Plasma Cells - immunology; Plasma Cells - metabolism; Polymerase chain reaction; Quantitative polymerase chain reaction; Remission (Medicine); Remission, Spontaneous; RNA - blood; RNA - genetics; RNA - immunology; Vein & artery diseases; Wegener's granulomatosis; Young Adult; Biomarkers; Granulomatosis with polyangiitis; Immunoglobulin G4; Disease activity; Quantitative polymerase chain reaction