The inhibition by human MSCs-derived miRNA-124a overexpression exosomes in the proliferation and migration of rheumatoid arthritis-related fibroblast-like synoviocyte cell

Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one...

Full description

Saved in:
Bibliographic Details
Published inBMC musculoskeletal disorders Vol. 21; no. 1; pp. 150 - 10
Main Authors Meng, Hong-Yan, Chen, Li-Qing, Chen, Li-Hui
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 06.03.2020
BioMed Central
BMC
Subjects
Adenoviruses
Angiogenesis
Antirheumatic agents
Apoptosis
Apoptosis - genetics
Arthritis
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Cartilage
Cell adhesion & migration
Cell cycle
Cell Cycle Checkpoints - genetics
Cell growth
Cell Line
Cell migration
Cell Movement - genetics
Cell physiology
Cell Proliferation - genetics
Coculture Techniques
Development and progression
Diseases
Exosome
Exosomes
Exosomes - metabolism
Fibroblast-like Synoviocytes
Fibroblasts
Fibroblasts - metabolism
Flow cytometry
Gene expression
Genetic aspects
Growth
Health aspects
Humans
Hyperplasia
Membranes
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
miRNA-124a
Musculoskeletal diseases
Osteoporosis
Proteins
Rheumatoid arthritis
Rheumatoid factor
Stem cell research
Stem cells
Synovial membrane
Synoviocytes - metabolism
Transfection
Wound healing
Wounds
China
miRNA-124a
Exosome
Rheumatoid arthritis
Fibroblast-like Synoviocytes
Mesenchymal stem cells
Online AccessGet full text
ISSN1471-2474
1471-2474
DOI10.1186/s12891-020-3159-y

Cover

Abstract Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
AbstractList Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. Methods The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Results Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Conclusions Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis. Keywords: Rheumatoid arthritis, Exosome, miRNA-124a, Mesenchymal stem cells, Fibroblast-like Synoviocytes
Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. Methods The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Results Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Conclusions Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
Abstract Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. Methods The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Results Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Conclusions Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis.BACKGROUNDRheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis.The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection.METHODSThe potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection.Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation.RESULTSExosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation.Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.CONCLUSIONSExosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like synoviocytes are the major cell types that make up the synovial intima structure, which is one of the decisive factors in the development and course of rheumatoid arthritis. The potential therapeutic effects of MSCs-derived miRNA-124a overexpression exosomes were evaluated in vitro by the method including MTT assay and cell cycle test for cell proliferation, scratch wound closure and transwell for cell migration, flow cytometry and western for the apoptosis detection. Exosomes derived from human MSCs that overexpression miRNA-124a were prepared and characterized. We found that the pretreatment of this exosome was able to inhibit the proliferation and migration of fibroblast-like synoviocyte cell line and promote the apoptosis of this cell during the co-incubation. Exosomes derived from MSCs were proved to be a suitable vector for the delivery of therapeutic miRNA-124a, and such miRNA-124a overexpression exosomes were expected to provide a new medicine and strategy for the treatment of rheumatoid arthritis.
ArticleNumber 150
Audience Academic
Author Chen, Li-Qing
Meng, Hong-Yan
Chen, Li-Hui
Author_xml – sequence: 1
  givenname: Hong-Yan
  surname: Meng
  fullname: Meng, Hong-Yan
– sequence: 2
  givenname: Li-Qing
  surname: Chen
  fullname: Chen, Li-Qing
– sequence: 3
  givenname: Li-Hui
  surname: Chen
  fullname: Chen, Li-Hui
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32143603$$D View this record in MEDLINE/PubMed
BookMark eNp9ksuO0zAUhiM0iLnAA7BBkdiwyeBLLs4Gqaq4jDSABMPasp3jxiWxi51Uk2fiJXHaMmpHCGXh2P7_7_gc_ZfJmXUWkuQlRtcYs_JtwITVOEMEZRQXdTY9SS5wXuGM5FV-dvR_nlyGsEYIV4zWz5JzSnBOS0Qvkt93LaTGtkaawTibyiltx17Y9PP3Zcga8GYLTdqbb18WGSa5SN0WPNxvPIQw6-HeBddDiIx0iKiNd53R4MWOJuzsXR12Tqe-hUgfnGlS4YfWx6Ih89CJIVbRRnonOxGGrDM_IQ2TdVvj1DRAqqDrnidPtegCvDisV8mPD-_vlp-y268fb5aL20wVJRoyzFiZIwCZi6KuFFVSA65riZoSWEUIoqRhRJS4pKJGgCWiTDZCUVmrmipCr5KbPbdxYs033vTCT9wJw3cHzq94fLxRHfCcQpylFDXVNIe6kbQoGNVaFAghqZvIerdnbUbZQ6PADl50J9DTG2tavnJbXqESFYRFwJsDwLtfI4SB9ybM0xAW3Bg4oVVOccnQLH39SLp2o7dxVLOKVbio6JFqJWIDxmoX66oZyhclrvA8ojyqrv-hil8DvVExhtrE8xPDq-NGHzr8G7UowHuB8i4ED_pBghGf48z3ceYxznyOM5-ip3rkUWbYhSm-xnT_cf4BGir8KA
CitedBy_id crossref_primary_10_1007_s10142_024_01404_0
crossref_primary_10_1155_2021_1530445
crossref_primary_10_1111_prd_12561
crossref_primary_10_1007_s00296_021_04798_3
crossref_primary_10_1007_s12013_024_01316_7
crossref_primary_10_3389_fimmu_2022_939433
crossref_primary_10_2147_IJN_S452184
crossref_primary_10_1007_s12013_024_01432_4
crossref_primary_10_3389_fimmu_2024_1499929
crossref_primary_10_1016_j_prp_2023_154332
crossref_primary_10_1016_j_intimp_2023_111365
crossref_primary_10_2147_JIR_S488201
crossref_primary_10_1007_s12015_020_10040_7
crossref_primary_10_3389_fimmu_2023_1240747
crossref_primary_10_2147_JIR_S469032
crossref_primary_10_3390_vaccines11030687
crossref_primary_10_1016_j_lfs_2021_119458
crossref_primary_10_1007_s13770_024_00634_4
crossref_primary_10_3390_ijms22063023
crossref_primary_10_1186_s13287_024_03887_x
crossref_primary_10_3389_fimmu_2021_768771
crossref_primary_10_3389_fimmu_2020_01912
crossref_primary_10_3389_fimmu_2022_838884
crossref_primary_10_1007_s00109_022_02276_2
crossref_primary_10_1038_s41584_023_01010_7
crossref_primary_10_1039_D4BM00558A
crossref_primary_10_1016_j_jneuroim_2021_577640
crossref_primary_10_1016_j_phrs_2021_105680
crossref_primary_10_1093_stcltm_szac075
crossref_primary_10_3389_fimmu_2021_686155
crossref_primary_10_3724_zdxbyxb_2024_0148
crossref_primary_10_1002_advs_202305116
crossref_primary_10_1038_s41413_023_00244_1
crossref_primary_10_1016_j_freeradbiomed_2021_08_235
crossref_primary_10_1186_s13287_022_03015_7
crossref_primary_10_3389_fimmu_2023_1153901
crossref_primary_10_4103_bbrj_bbrj_142_24
crossref_primary_10_1016_j_jconrel_2025_113610
crossref_primary_10_3390_cells13110915
crossref_primary_10_3389_fimmu_2020_01509
crossref_primary_10_3389_fimmu_2021_643170
crossref_primary_10_1016_j_heliyon_2024_e33062
crossref_primary_10_1089_ten_teb_2023_0208
crossref_primary_10_1016_j_humgen_2024_201352
crossref_primary_10_1186_s40001_023_01034_5
crossref_primary_10_1016_j_biopha_2022_113126
crossref_primary_10_1016_j_heliyon_2024_e28127
crossref_primary_10_1016_j_reth_2024_08_001
crossref_primary_10_1007_s13577_020_00419_6
crossref_primary_10_3390_cells12232716
crossref_primary_10_1080_09540105_2023_2220566
crossref_primary_10_3390_biomedicines10071725
crossref_primary_10_1002_jex2_156
crossref_primary_10_1186_s40824_023_00418_2
crossref_primary_10_3390_pharmaceutics14040733
crossref_primary_10_1186_s12967_021_02980_6
Cites_doi 10.1016/j.ejca.2010.11.026
10.7150/thno.21072
10.3390/cells8050467
10.1007/s00296-012-2657-0
10.4049/jimmunol.1800304
10.1186/ar4355
10.1186/ar4194
10.1038/nrm2347
10.1517/14712590902932889
10.1093/rheumatology/kel267
10.1016/j.scr.2009.12.003
10.3233/JIN-170052
10.1038/nature01661
10.1097/01.TP.0000045055.63901.A9
10.1016/j.nano.2015.10.011
10.1002/jor.1100090504
10.1111/j.1582-4934.2007.00196.x
10.1089/scd.2013.0023
10.1002/art.25018
10.1111/j.0105-2896.2009.00859.x
10.1038/sc.2009.89
10.1002/art.24475
10.1002/art.23386
10.1111/2049-632X.12135
10.1016/j.biomaterials.2016.03.025
10.1136/annrheumdis-2014-206417
10.1002/art.30115
10.31083/j.rcm.2019.03.528
10.1007/s10067-011-1816-0
10.1016/j.expneurol.2009.06.015
10.1016/j.intimp.2018.09.049
10.1038/nrurol.2013.113
10.1182/blood-2003-04-1193
ContentType Journal Article
Copyright COPYRIGHT 2020 BioMed Central Ltd.
2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s). 2020
Copyright_xml – notice: COPYRIGHT 2020 BioMed Central Ltd.
– notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s). 2020
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QP
7RV
7TK
7TS
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
KB0
M0S
M1P
NAPCQ
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12891-020-3159-y
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Nursing & Allied Health Database
Neurosciences Abstracts
Physical Education Index
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Health & Medical Collection
Medical Database
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
Physical Education Index
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1471-2474
EndPage 10
ExternalDocumentID oai_doaj_org_article_43e321ba93f34e9db35583ffa5000bfd
PMC7060528
A617187224
32143603
10_1186_s12891_020_3159_y
Genre Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GroupedDBID ---
0R~
23N
2WC
53G
5VS
6J9
6PF
7RV
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAWTL
AAYXX
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
INH
INR
ITC
KQ8
M1P
M48
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSV
SMD
SOJ
SV3
TR2
TUS
U2A
UKHRP
W2D
WOQ
WOW
XSB
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7QP
7TK
7TS
7XB
8FK
AZQEC
DWQXO
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c560t-188640eeb4a597c3cbfe199b0d6e8722032d82a6163a90e1b038bdac3b9c93c23
IEDL.DBID M48
ISSN 1471-2474
IngestDate Wed Aug 27 01:31:24 EDT 2025
Thu Aug 21 18:12:57 EDT 2025
Fri Jul 11 13:20:14 EDT 2025
Fri Jul 25 07:24:07 EDT 2025
Tue Jun 17 20:32:12 EDT 2025
Tue Jun 10 20:42:21 EDT 2025
Thu Apr 03 07:06:36 EDT 2025
Thu Apr 24 22:51:54 EDT 2025
Tue Jul 01 01:09:00 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords miRNA-124a
Exosome
Rheumatoid arthritis
Fibroblast-like Synoviocytes
Mesenchymal stem cells
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c560t-188640eeb4a597c3cbfe199b0d6e8722032d82a6163a90e1b038bdac3b9c93c23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/43e321ba93f34e9db35583ffa5000bfd
PMID 32143603
PQID 2378715738
PQPubID 44767
PageCount 10
ParticipantIDs doaj_primary_oai_doaj_org_article_43e321ba93f34e9db35583ffa5000bfd
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7060528
proquest_miscellaneous_2374316808
proquest_journals_2378715738
gale_infotracmisc_A617187224
gale_infotracacademiconefile_A617187224
pubmed_primary_32143603
crossref_primary_10_1186_s12891_020_3159_y
crossref_citationtrail_10_1186_s12891_020_3159_y
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-03-06
PublicationDateYYYYMMDD 2020-03-06
PublicationDate_xml – month: 03
  year: 2020
  text: 2020-03-06
  day: 06
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle BMC musculoskeletal disorders
PublicationTitleAlternate BMC Musculoskelet Disord
PublicationYear 2020
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References B Zhang (3159_CR7) 2008; 12
MA Cortez (3159_CR9) 2009; 9
A Fowler (3159_CR14) 2011; 47
G Hu (3159_CR30) 2012; 3
N-K Liu (3159_CR36) 2009; 219
A Fleming (3159_CR29) 2014; 71
SH Taj (3159_CR31) 2016; 91
3159_CR25
K Nakanishi (3159_CR35) 2010; 48
H Yoshino (3159_CR8) 2013; 10
W Jiang (3159_CR21) 2019; 20
X Luo (3159_CR11) 2013; 15
RC Lai (3159_CR20) 2010; 4
GS Firestein (3159_CR1) 2003; 423
Y Nakamachi (3159_CR15) 2009; 60
E Karouzakis (3159_CR2) 2009; 60
J Stanczyk (3159_CR10) 2008; 58
AM Louw (3159_CR32) 2016; 12
CR Harrell (3159_CR28) 2019; 8
S Cosenza (3159_CR27) 2018; 8
L Yu (3159_CR13) 2018; 17
X Ni (3159_CR22) 2018; 17
J Liang (3159_CR26) 2012; 31
C Bocelli-Tyndall (3159_CR23) 2006; 46
Y Wang (3159_CR34) 2018; 65
B Bartok (3159_CR3) 2010; 233
J Tian (3159_CR4) 2013; 33
L Wang (3159_CR18) 2013; 22
J Stanczyk (3159_CR12) 2011; 63
L Klareskog (3159_CR5) 2004; 63
Z Chen (3159_CR16) 2018; 201
AI Caplan (3159_CR17) 1991; 9
Z Zhang (3159_CR24) 2013; 15
Y Nakamachi (3159_CR33) 2016; 75
F Djouad (3159_CR19) 2003; 102
G Stefani (3159_CR6) 2008; 9
References_xml – volume: 47
  start-page: 953
  issue: 6
  year: 2011
  ident: 3159_CR14
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.11.026
– volume: 8
  start-page: 1399
  issue: 5
  year: 2018
  ident: 3159_CR27
  publication-title: Theranostics
  doi: 10.7150/thno.21072
– volume: 8
  start-page: 467
  issue: 5
  year: 2019
  ident: 3159_CR28
  publication-title: Cells
  doi: 10.3390/cells8050467
– volume: 33
  start-page: 1829
  issue: 7
  year: 2013
  ident: 3159_CR4
  publication-title: Rheumatol Int
  doi: 10.1007/s00296-012-2657-0
– volume: 201
  start-page: 2472
  issue: 8
  year: 2018
  ident: 3159_CR16
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1800304
– volume: 15
  start-page: R169
  issue: 5
  year: 2013
  ident: 3159_CR24
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar4355
– volume: 15
  start-page: 210
  issue: 2
  year: 2013
  ident: 3159_CR11
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar4194
– volume: 9
  start-page: 219
  issue: 3
  year: 2008
  ident: 3159_CR6
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2347
– volume: 9
  start-page: 703
  issue: 6
  year: 2009
  ident: 3159_CR9
  publication-title: Expert Opin Biol Ther
  doi: 10.1517/14712590902932889
– volume: 46
  start-page: 403
  issue: 3
  year: 2006
  ident: 3159_CR23
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kel267
– volume: 4
  start-page: 214
  issue: 3
  year: 2010
  ident: 3159_CR20
  publication-title: Stem Cell Res
  doi: 10.1016/j.scr.2009.12.003
– volume: 17
  start-page: 203
  issue: 2
  year: 2018
  ident: 3159_CR22
  publication-title: J Integr Neurosci
  doi: 10.3233/JIN-170052
– volume: 423
  start-page: 356
  issue: 6937
  year: 2003
  ident: 3159_CR1
  publication-title: Nature
  doi: 10.1038/nature01661
– ident: 3159_CR25
  doi: 10.1097/01.TP.0000045055.63901.A9
– volume: 12
  start-page: 643
  issue: 3
  year: 2016
  ident: 3159_CR32
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2015.10.011
– volume: 9
  start-page: 641
  issue: 5
  year: 1991
  ident: 3159_CR17
  publication-title: J Orthop Res
  doi: 10.1002/jor.1100090504
– volume: 12
  start-page: 3
  issue: 1
  year: 2008
  ident: 3159_CR7
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2007.00196.x
– volume: 22
  start-page: 3192
  issue: 24
  year: 2013
  ident: 3159_CR18
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2013.0023
– volume: 60
  start-page: 3613
  issue: 12
  year: 2009
  ident: 3159_CR2
  publication-title: Arthritis Rheum
  doi: 10.1002/art.25018
– volume: 233
  start-page: 233
  issue: 1
  year: 2010
  ident: 3159_CR3
  publication-title: Immunol Rev
  doi: 10.1111/j.0105-2896.2009.00859.x
– volume: 48
  start-page: 192
  issue: 3
  year: 2010
  ident: 3159_CR35
  publication-title: Spinal Cord
  doi: 10.1038/sc.2009.89
– volume: 63
  start-page: ii28
  issue: suppl 2
  year: 2004
  ident: 3159_CR5
  publication-title: Ann Rheum Dis
– volume: 60
  start-page: 1294
  issue: 5
  year: 2009
  ident: 3159_CR15
  publication-title: Arthritis Rheum
  doi: 10.1002/art.24475
– volume: 58
  start-page: 1001
  issue: 4
  year: 2008
  ident: 3159_CR10
  publication-title: Arthritis Rheum
  doi: 10.1002/art.23386
– volume: 71
  start-page: 109
  issue: 2
  year: 2014
  ident: 3159_CR29
  publication-title: Pathog Dis
  doi: 10.1111/2049-632X.12135
– volume: 91
  start-page: 151
  year: 2016
  ident: 3159_CR31
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2016.03.025
– volume: 75
  start-page: 601
  issue: 3
  year: 2016
  ident: 3159_CR33
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2014-206417
– volume: 3
  start-page: 56
  year: 2012
  ident: 3159_CR30
  publication-title: Front Genet
– volume: 63
  start-page: 373
  issue: 2
  year: 2011
  ident: 3159_CR12
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30115
– volume: 20
  start-page: 153
  issue: 3
  year: 2019
  ident: 3159_CR21
  publication-title: Rev Cardiovasc Med
  doi: 10.31083/j.rcm.2019.03.528
– volume: 31
  start-page: 157
  issue: 1
  year: 2012
  ident: 3159_CR26
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-011-1816-0
– volume: 219
  start-page: 424
  issue: 2
  year: 2009
  ident: 3159_CR36
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2009.06.015
– volume: 65
  start-page: 284
  year: 2018
  ident: 3159_CR34
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2018.09.049
– volume: 10
  start-page: 396
  issue: 7
  year: 2013
  ident: 3159_CR8
  publication-title: Nat Rev Urol
  doi: 10.1038/nrurol.2013.113
– volume: 102
  start-page: 3837
  issue: 10
  year: 2003
  ident: 3159_CR19
  publication-title: Blood
  doi: 10.1182/blood-2003-04-1193
– volume: 17
  start-page: 3972
  issue: 3
  year: 2018
  ident: 3159_CR13
  publication-title: Mol Med Rep
SSID ssj0017839
Score 2.4971726
Snippet Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint...
Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and...
Abstract Background Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling,...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 150
SubjectTerms Adenoviruses
Angiogenesis
Antirheumatic agents
Apoptosis
Apoptosis - genetics
Arthritis
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Cartilage
Cell adhesion & migration
Cell cycle
Cell Cycle Checkpoints - genetics
Cell growth
Cell Line
Cell migration
Cell Movement - genetics
Cell physiology
Cell Proliferation - genetics
Coculture Techniques
Development and progression
Diseases
Exosome
Exosomes
Exosomes - metabolism
Fibroblast-like Synoviocytes
Fibroblasts
Fibroblasts - metabolism
Flow cytometry
Gene expression
Genetic aspects
Growth
Health aspects
Humans
Hyperplasia
Membranes
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
miRNA-124a
Musculoskeletal diseases
Osteoporosis
Proteins
Rheumatoid arthritis
Rheumatoid factor
Stem cell research
Stem cells
Synovial membrane
Synoviocytes - metabolism
Transfection
Wound healing
Wounds
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQUB6hBRkJgYRkNYkTr31cKqoKqT0AlXqzYmfCRnSTqkmr5jfxJ5lxsquNkODCMfE4iT3jecTjbxh7572WhSpTUUkDIivShSjQ6gk6dOlc4goXdnTPztXpRfblMr_cKfVFOWEjPPA4cUeZBJliHyMrmYEpHeGBy6oKSP6uKkn7os3bBFPT_sEC7f60h5loddShFqYMn3BaODdimFmhANb_p0resUnzfMkdA3TymD2aPEe-HL_4CXsAzVO2v2wwal4P_D0PuZzhJ_k--4Xc53Wzql3IyOJu4KEYHz_7dtyJEqXuDkq-rr-eLwWa3oJTIifcT0mxDYf7tmvX0OEzOHqI_Jpq-1QwSgsvGur7Y7pqK36zAnx639YlxwldBZwkEU7J4FsqDMhbh056L67qn8C7oWnv6tYPPXDaNnjGLk4-fz8-FVNZBuHRPepForXKYgCXFRiNeOldBYkxLi4V6EVKJdlLnRYKPb3CxJC4WGpXFl464430qXzO9pq2gZeMQ6yMzkEBqpIM3XztKpNppU2VGqdARSzesMn6CbOcSmdc2RC7aGVHzlrkrCXO2iFiH7ddrkfAjr8RfyLebwkJazvcQAm0kwTaf0lgxD6Q5FjSCPhxvpgONuAQCVvLLtFJTGhisogdzihxJft580b27KRJOptKVKlJvpA6Ym-3zdSTsuMaaG8DDSEa6BhpXoyiuh0SFaKSKpYRW8yEeDbmeUtTrwLOOAEr5al-9T8m6YA9TGn5hdqVh2yvv7mF1-jO9e5NWLm_Aa9mSws
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELZgvPCCgPEjMJCREEhI1pI4de0nVCamCWl7ACb1LYqdyxqxJqXJpuVv4p_kznXLIqQ9tj6nce_z3dk-f8fYe-e0LFSZikoaEFmRTkWBXk_QpUtrE1tYf6J7eqZOzrNv88k8bLh1Ia1yaxO9oS5bR3vkh6lEaCWTqdSfV78FVY2i09VQQuM-e0DUZZTSNZ3vFlzJFL1_OMlMtDrs0BZTno-_MzwxYhj5Ik_Z_79hvuWZxlmTt9zQ8WP2KMSPfLZR-BN2D5qnbH_W4Np5OfAP3Gd0-q3yffYHMcDrZlFbn5fF7cB9ST5--uOoEyVi7xpKvqy_n80EOuCCUzon3ITU2IbDTdu1S-jwGRzjRL6iCj8VbDDDi4b6XoRPbcXXC8Cn921dcsTjwrMlCX9XBn-lwmV5azFU78Vl_Qt4NzTtdd26oQdOhwfP2Pnx159HJyIUZxAOg6ReJFqrLAawWYFrEiedrSAxxsalAj1NqTB7qdNCYbxXmBgSG0tty8JJa5yRLpXP2V7TNvCScYiV0RNQgAYlw2Bf28pkWmlTpcYqUBGLt2rKXWAupwIal7lfwWiVbzSbo2Zz0mw-ROzTrstqQ9txl_AX0v1OkBi3_Rft-iIPEzjPJMgUsWtkJTMwpSVeellVvqKErcqIfSTk5GQX8OVcEa434BCJYSufYaiY0B-TRexgJInz2Y2bt9jLgz3p8n_oj9i7XTP1pBy5BtorL0O8BjpGmRcbqO6GROWopIplxKYjEI_GPG5p6oVnGyd6pUmqX939Wq_Zw5Qmlq9NecD2-vUVvMFwrbdv_Zz8C5gVQjw
  priority: 102
  providerName: ProQuest
Title The inhibition by human MSCs-derived miRNA-124a overexpression exosomes in the proliferation and migration of rheumatoid arthritis-related fibroblast-like synoviocyte cell
URI https://www.ncbi.nlm.nih.gov/pubmed/32143603
https://www.proquest.com/docview/2378715738
https://www.proquest.com/docview/2374316808
https://pubmed.ncbi.nlm.nih.gov/PMC7060528
https://doaj.org/article/43e321ba93f34e9db35583ffa5000bfd
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLZ2eeEFAeMSGJWREEhIhiR2HfsBoW7aNCG1QoNKe7Nix1mjtclosqn5TfxJjt20LGJCPCa-JI6_43NOfHw-hN4aI2jKs5jkVFrC0jghKWg94g5dah3pVPsd3fGEn03Z14vhxQ7a0Ft1H7C-17VzfFLT5fzj6mf7BQT-sxd4wT_VsMa6-B1_FngoSbuL9kExJU5Ox-zPpkIiPLFYBOsxiVnCuk3Oe7voqSmfzf_vNfuO0uoHVN7RUKeP0MPOtMSjNRYeox1bPkEHoxLc6kWL32Ef7On_oh-gXwAPXJSzQvuQLaxb7Nn68Pj7cU0ygOWtzfCiOJ-MCOjmFLtIT7vqomZLbFdVXS1sDX1gMCHxtSP_ye0aTjgtXdvL7qrK8XJmofemKjIMUJ35RErEH6OBp-TgsVcarPiGzIsri-u2rG6LyrSNxW5f4Smanp78OD4jHW8DMWA_NSQSgrPQWs1ScFcMNTq3kZQ6zLgVSew42zMRpxxMwVSGNtIhFTpLDdXSSGpi-gztlVVpXyBsQy7F0HILaw0DP0DoXDLBhcxjqbnlAQo306RMl9TccWvMlXduBFfrmVUws8rNrGoD9GHb5Hqd0eNflY_c3G8rumTc_ka1vFSdbCtGLY0B1pLmlFmZaZeynua5J5vQeRag9w45yoEYXs6k3ckHGKJLvqVGYEVG7sOwAB32aoKom37xBntqIykqprDmRsOEigC92Ra7li58rrTVja_jUh6IEOo8X0N1OyTHVEV5SAOU9EDcG3O_pCxmPhG5y7w0jMXL_3juK_QgdtLluSsP0V6zvLGvwZxr9ADtJhfJAO0fnUy-nQ_8T5GBF9zfxVRMwA
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bT9RAFJ4QeNAXo-JlFXVMvCQmE9pOtzvzYMyCEBDYGISEt7EzPWUboUW6IP1NJv5Gz5ntrjQmvPHYnZm2s-c6PZePsTfOKZkmWSRyqUHEaTQQKVo9QUWX1oY2tT6iuzdKtg7jL0f9owX2Z1YLQ2mVM53oFXVWOfpGvhpJZK2wP5Dq09lPQahRFF2dQWhM2WIHml94ZKs_bn9G-r6Nos2Ng_Ut0aIKCIfWfSJCpZI4ALBxis60k87mEGptgywBNYgIUTxTUZqgo5LqAEIbSGWz1EmrnZaOGh2gyl-KJR5lFtnS2sbo6_48bjFAf6ONnYYqWa1R-1Nmka9S7mvRdKyfBwn43xRcs4XdPM1rhm_zPrvXeqx8OGWxB2wByodseVjiaf204e-4zyH1H-eX2W_kOl6U48L6TDBuG-5BAPnet_VaZMjtl5Dx02J_NBRo8lNOCaRw1Sbjlhyuqro6hRrvwdEz5WeEKZTDlEt5WtLa4_aqyvn5GPDuk6rIOErA2PdnEr46B5-SF5bActJ6Ik6KH8Drpqwui8o1E-AUrnjEDm-FcI_ZYlmV8JRxCBKt-pAAqrAYjxfK5jpWidJ5pG0CSY8FMzIZ1_ZKJ8iOE-PPTCoxU8oapKwhypqmxz7Ml5xNG4XcNHmNaD-fSD2-_Q_V-bFpVYaJJcgIpUXLXMagM0ud8GWeewwLm2c99p44x5AmwpdzaVtQgVuknl5miM5pSH9M3GMrnZmoQVx3eMZ7ptVgtfknbz32ej5MKykrr4Tqws-hTgoqwDlPpqw63xIBYKGIyB4bdJi4s-fuSFmMfX9zaujUj9Szm1_rFbuzdbC3a3a3RzvP2d2IhMwjY66wxcn5BbxAZ3FiX7YSytn321YKfwFx-oAr
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+inhibition+by+human+MSCs-derived+miRNA-124a+overexpression+exosomes+in+the+proliferation+and+migration+of+rheumatoid+arthritis-related+fibroblast-like+synoviocyte+cell&rft.jtitle=BMC+musculoskeletal+disorders&rft.au=Meng%2C+Hong-Yan&rft.au=Chen%2C+Li-Qing&rft.au=Chen%2C+Li-Hui&rft.date=2020-03-06&rft.issn=1471-2474&rft.eissn=1471-2474&rft.volume=21&rft.issue=1&rft.spage=150&rft_id=info:doi/10.1186%2Fs12891-020-3159-y&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2474&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2474&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2474&client=summon