Natural history of chronic hepatitis B virus infection from infancy to adult life -the mechanism of inflammation triggering and long-term impacts

• Published in: Journal of biomedical science Vol. 22; no. 1; p. 92
• Main Authors: Wu, Jia-Feng, Chang, Mei-Hwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.10.2015; BioMed Central
• Subjects: Adolescent; Adult; Antigens; Biosynthesis; Child; Child, Preschool; Development and progression; DNA, Viral - genetics; DNA, Viral - metabolism; Female; Hepatitis; Hepatitis B; Hepatitis B e Antigens - genetics; Hepatitis B e Antigens - metabolism; Hepatitis B virus; Hepatitis B virus - physiology; Hepatitis B, Chronic - genetics; Hepatitis B, Chronic - metabolism; Hepatitis B, Chronic - pathology; Histocompatibility antigens; HLA histocompatibility antigens; Host-Pathogen Interactions; Humans; Immune response; Infant; Infection; Inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Liver; Liver - metabolism; Liver - pathology; Liver - virology; Liver cirrhosis; Male; Pathogenesis; Physiological aspects; Review; Transcription factors; Taiwan

Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood and persists lifelong. The clinical course varies among different chronic infected subjects. Majority of chronic HBV infected children present with immune-tolerant status initially, experience...