The gut, its microbiome, and the brain: connections and communications

• Published in: The Journal of clinical investigation Vol. 131; no. 18
• Main Authors: Gershon, Michael D., Margolis, Kara Gross
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.09.2021
• Subjects: Animals; Brain - physiology; Brain research; Cellular signal transduction; Connectome; Enteric Nervous System - physiology; Gastrointestinal Microbiome - immunology; Gastrointestinal Microbiome - physiology; Gastrointestinal Tract - immunology; Gastrointestinal Tract - physiology; Health aspects; Humans; Intestine, Small; Macrophages - immunology; Microbiota (Symbiotic organisms); Models, Neurological; Nervous system, Autonomic; Neural Pathways - physiology; Neurophysiology; Physiological aspects; Review Series; United States

Modern research on gastrointestinal behavior has revealed it to be a highly complex bidirectional process in which the gut sends signals to the brain, via spinal and vagal visceral afferent pathways, and receives sympathetic and parasympathetic inputs. Concomitantly, the enteric nervous system withi...