Abnormal resting-state functional connectivity of the nucleus accumbens in multi-year abstinent heroin addicts

• Published in: Journal of neuroscience research Vol. 93; no. 11; pp. 1693 - 1702
• Main Authors: Zou, Feng, Wu, Xinhuai, Zhai, Tianye, Lei, Yu, Shao, Yongcong, Jin, Xiao, Tan, Shuwen, Wu, Bing, Wang, Lubin, Yang, Zheng
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: abstinence; Adult; Cross-Sectional Studies; Female; functional connectivity; heroin dependence; Heroin Dependence - pathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neural Pathways - pathology; nucleus accumbens; Nucleus Accumbens - pathology; resting state; abstinence; resting state; functional connectivity; nucleus accumbens; heroin dependence

Functional neuroimaging studies suggest that abnormal brain functional connectivity may be the neural underpinning of addiction to illicit drugs and of relapse after successful cessation therapy. Aberrant brain networks have been demonstrated in addicted patients and in newly abstinent addicts. Howe...