Colonic bacterial composition in Parkinson's disease

• Published in: Movement disorders Vol. 30; no. 10; pp. 1351 - 1360
• Main Authors: Keshavarzian, Ali, Green, Stefan J., Engen, Phillip A., Voigt, Robin M., Naqib, Ankur, Forsyth, Christopher B., Mutlu, Ece, Shannon, Kathleen M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2015; Wiley Subscription Services, Inc
• Subjects: a-synuclein; Adult; Aged; alpha-Synuclein - chemistry; Colon, Sigmoid - microbiology; colonic mucosa and feces; dysbiosis; Dysbiosis - complications; Feces - microbiology; Female; Humans; Intestinal Mucosa - microbiology; Male; Microbiota; Middle Aged; Movement disorders; Parkinson Disease - etiology; Protein Folding; Proteobacteria; putative butyrate producing short-chain fatty acids; Ralstonia; microbiota; putative butyrate producing short-chain fatty acids; a-synuclein; colonic mucosa and feces; dysbiosis

Introduction We showed that Parkinson's disease (PD) patients have alpha‐synuclein (α‐Syn) aggregation in their colon with evidence of colonic inflammation. If PD patients have altered colonic microbiota, dysbiosis might be the mechanism of neuroinflammation that leads to α‐Syn misfolding and P...