Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity

• Published in: Nature communications Vol. 14; no. 1; pp. 1715 - 15
• Main Authors: He, Shuwen, Gillies, John P., Zang, Juliana L., Córdoba-Beldad, Carmen M., Yamamoto, Io, Fujiwara, Yasuhiro, Grantham, Julie, DeSantis, Morgan E., Shibuya, Hiroki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/63; 38/1; 38/77; 38/89; 631/136/2434/1822; 631/80/128/1441; 631/80/641/1633; 64/60; 82/111; Animals; Biologi; Biological Sciences; Bipolarity; Cell Biology; Cellbiologi; Centrosome - metabolism; Centrosomes; Chains; Dynein; Dyneins - genetics; Dyneins - metabolism; Gametocytes; Humanities and Social Sciences; Male; Males; Meiosis; Metaphase; Mice; multidisciplinary; Regulatory mechanisms (biology); Science; Science (multidisciplinary); Spindle Apparatus - metabolism; Spindles; Yeast

Spindle formation in male meiosis relies on the canonical centrosome system, which is distinct from acentrosomal oocyte meiosis, but its specific regulatory mechanisms remain unknown. Herein, we report that DYNLRB2 (Dynein light chain roadblock-type-2) is a male meiosis-upregulated dynein light chai...