Delayed Effects of Sublethal Ischemia on the Acquisition of Tolerance to Ischemia

• Published in: Circulation research Vol. 72; no. 6; pp. 1293 - 1299
• Main Authors: Kuzuya, Tsunehiko, Hoshida, Shiro, Yamashita, Nobushige, Fuji, Hisakazu, Oe, Hiroshi, Hori, Masatsugu, Kamada, Takenobu, Tada, Michihiko
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.06.1993; Lippincott
• Subjects: Animals; Biological and medical sciences; Cardiology. Vascular system; Coronary Circulation; Coronary heart disease; Disease Models, Animal; Disease Susceptibility; Dogs; Female; Heart; Hemodynamics; Male; Medical sciences; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardial Ischemia - physiopathology; Myocardial Reperfusion Injury - physiopathology; Time Factors; Experimental disease; Reperfusion; Sensitivity resistance; Infarct; Ischemia; Animal; Risk factor; Myocardium; Tolerance; Cardiovascular disease; Hemodynamics; Coronary heart disease

The infarct-limiting effect of ischemic preconditioning is believed to be a transient phenomenon. We examined the delayed effects of repetitive brief ischemia on limiting infarct size in an open-chest dog model by an occlusion (90 minutes) of the left anterior descending coronary artery (LAD) follow...