Glutamate receptor activation can trigger electrical activity in human glioma cells

• Published in: The European journal of neuroscience Vol. 10; no. 6; pp. 2153 - 2162
• Main Authors: Labrakakis, Charalampos, Patt, Stephan, Hartmann, Jana, Kettenmann, Helmut
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.06.1998
• Subjects: Ca2+ channels; Calcium - metabolism; Calcium Channels - metabolism; Electric Conductivity; Electrophysiology; glioma; Glioma - metabolism; Glioma - pathology; Glioma - physiopathology; glutamate receptors; Glutamic Acid - pharmacology; human; Humans; Intracellular Membranes - metabolism; Ion Channel Gating - physiology; Kainic Acid - pharmacology; Osmolar Concentration; patch-clamp; Potassium - physiology; Receptors, Glutamate - physiology; Tumor Cells, Cultured - drug effects

Cells from major types of gliomas, i.e. oligodendrogliomas and glioblastomas, are able to generate action potentials upon a current injection similar to neurons (Patt et al. (1996) Neuroscience, 71, 601–611; Labrakakis et al. (1997b) J. Neuropath. Exp. Neurol., 56, 243–254. Here, we report that acti...