The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials

Summary This study provides a systematic review and meta‐analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and referen...

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Published inObesity reviews Vol. 17; no. 10; pp. 970 - 976
Main Authors Pooyandjoo, M., Nouhi, M., Shab-Bidar, S., Djafarian, K., Olyaeemanesh, A.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.10.2016
Wiley Subscription Services, Inc
Subjects
(L-)carnitine
BMI
Carnitine - pharmacology
Carnitine - therapeutic use
Dietary Supplements
Fatty Acids - metabolism
Humans
meta-analysis
Obesity - drug therapy
Obesity - prevention & control
Randomized Controlled Trials as Topic
Treatment Outcome
weight change
Weight Loss - drug effects
meta-analysis
(L-)carnitine
weight change
BMI
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Abstract Summary This study provides a systematic review and meta‐analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n = 911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta‐analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: −1.33 kg; 95% CI: −2.09 to −0.57) and showed a decrease in body mass index (MD: −0.47 kg m−2; 95% CI: −0.88 to −0.05) compared with the control group. The results of meta‐regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p = 0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple‐treatments meta‐analysis of the drugs and non‐pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity
AbstractList This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n=911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta-analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: -1.33kg; 95% CI: -2.09 to -0.57) and showed a decrease in body mass index (MD: -0.47kgm super(-2); 95% CI: -0.88 to -0.05) compared with the control group. The results of meta-regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p=0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple-treatments meta-analysis of the drugs and non-pharmacotherapy options seem to be insightful areas for research. copyright 2016 World Obesity
This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n = 911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta-analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: -1.33 kg; 95% CI: -2.09 to -0.57) and showed a decrease in body mass index (MD: -0.47 kg m(-2) ; 95% CI: -0.88 to -0.05) compared with the control group. The results of meta-regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p = 0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple-treatments meta-analysis of the drugs and non-pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity.
Summary This study provides a systematic review and meta‐analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n = 911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta‐analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: −1.33 kg; 95% CI: −2.09 to −0.57) and showed a decrease in body mass index (MD: −0.47 kg m−2; 95% CI: −0.88 to −0.05) compared with the control group. The results of meta‐regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p = 0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple‐treatments meta‐analysis of the drugs and non‐pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity
Summary This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n=911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta-analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: -1.33kg; 95% CI: -2.09 to -0.57) and showed a decrease in body mass index (MD: -0.47kgm-2; 95% CI: -0.88 to -0.05) compared with the control group. The results of meta-regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time (p=0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple-treatments meta-analysis of the drugs and non-pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity
Summary This study provides a systematic review and meta‐analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight loss. Relevant studies were identified by systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials and reference lists of relevant marker studies. Nine studies (total n  = 911) of adequate methodological quality were included in the review. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Results from meta‐analysis of eligible trials revealed that subjects who received carnitine lost significantly more weight (MD: −1.33 kg; 95% CI: −2.09 to −0.57) and showed a decrease in body mass index (MD: −0.47 kg m −2 ; 95% CI: −0.88 to −0.05) compared with the control group. The results of meta‐regression analysis of duration of consumption revealed that the magnitude of weight loss resulted by carnitine supplementation significantly decreased over time ( p  = 0.002). We conclude that receiving the carnitine resulted in weight loss. Using multiple‐treatments meta‐analysis of the drugs and non‐pharmacotherapy options seem to be insightful areas for research. © 2016 World Obesity
Author Olyaeemanesh, A.
Nouhi, M.
Djafarian, K.
Shab-Bidar, S.
Pooyandjoo, M.
Author_xml – sequence: 1
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  surname: Pooyandjoo
  fullname: Pooyandjoo, M.
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  surname: Nouhi
  fullname: Nouhi, M.
  organization: Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
– sequence: 3
  givenname: S.
  surname: Shab-Bidar
  fullname: Shab-Bidar, S.
  organization: Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
– sequence: 4
  givenname: K.
  surname: Djafarian
  fullname: Djafarian, K.
  email: kdjafarian@tums.ac.ir, kdjafarian@tums.ac.ir
  organization: Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
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weight change
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2007; 147
2010; 11
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2007; 369
2004; 27
2002; 50
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2008; 1
2008; 94
2008; 120
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2013; 10
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2003; 25
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Snippet Summary This study provides a systematic review and meta‐analysis of randomized controlled trials, which have examined the effect of the carnitine on adult...
This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult weight...
Summary This study provides a systematic review and meta-analysis of randomized controlled trials, which have examined the effect of the carnitine on adult...
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SubjectTerms (L-)carnitine
BMI
Carnitine - pharmacology
Carnitine - therapeutic use
Dietary Supplements
Fatty Acids - metabolism
Humans
meta-analysis
Obesity - drug therapy
Obesity - prevention & control
Randomized Controlled Trials as Topic
Treatment Outcome
weight change
Weight Loss - drug effects
Title The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials
URI https://api.istex.fr/ark:/67375/WNG-LFZ362DB-Z/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fobr.12436
https://www.ncbi.nlm.nih.gov/pubmed/27335245
https://www.proquest.com/docview/1817942281
https://search.proquest.com/docview/1818342394
https://search.proquest.com/docview/1827911256
Volume 17
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