Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects - Nguyen, Linh; Holland, Jaymes; Mamelok, Richard; Laberge, Marie-Kristine; Grenier, Julie; Swearingen, Dennis; Armas, Danielle; Lacy, Steven (Journal of clinical pharmacology, 2015)
Keywords: Adolescent; Adult; Anilides - adverse effects; Anilides - blood; Anilides - pharmacokinetics; Biological Availability; Cross-Over Studies; Drug Interactions; Esomeprazole - pharmacology; Female; Food; Healthy Volunteers; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Protein Kinase Inhibitors - adverse effects; Protein Kinase Inhibitors - blood; Protein Kinase Inhibitors - pharmacokinetics; Proton Pump Inhibitors - pharmacology; Pyridines - adverse effects; Pyridines - blood; Pyridines - pharmacokinetics; Stomach - metabolism; Young Adult; pharmacokinetics; drug interactions; food effect; proton pump inhibitor; cabozantinib