M2 macrophages and regulatory T cells in lethal prostate cancer

• Published in: The Prostate Vol. 79; no. 4; pp. 363 - 369
• Main Authors: Erlandsson, Ann, Carlsson, Jessica, Lundholm, Marie, Fält, Anna, Andersson, Sven‐Olof, Andrén, Ove, Davidsson, Sabina
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Antigens, CD - analysis; Antigens, Differentiation, Myelomonocytic - analysis; Case-Control Studies; CD163; CD163 antigen; CD4 antigen; Cell Count; Cohort Studies; Folkhälsovetenskap; FOXP3; Foxp3 protein; Humans; Immunohistochemistry; Immunoregulation; Inflammation; Lymphocyte Count; Lymphocytes T; Macrophages; Macrophages - chemistry; Macrophages - immunology; Macrophages - pathology; Male; Original; Prognosis; Prostate cancer; Prostatic Neoplasms - immunology; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Public Health Science; Receptors, Cell Surface - analysis; Risk Factors; Suppressor cells; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - pathology; TAMs; Transurethral Resection of Prostate; Tregs; CD163; TAMs; FOXP3; Tregs

Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the world. Emerging evidence suggests that inflammatory cells such as M2 macrophages and regulatory T cells (Tregs) can contribute to cancer progression by suppressing the anti‐tumor immune response. This study inves...