Design and analysis of nested case–control studies for recurrent events subject to a terminal event

• Published in: Statistics in Medicine Vol. 38; no. 22; pp. 4348 - 4362
• Main Authors: Jazić, Ina, Haneuse, Sebastien, French, Benjamin, MacGrogan, Gaëtan, Rondeau, Virginie
• Format: Journal Article
• Language: English
• Published: England Wiley 30.09.2019; Wiley Subscription Services, Inc; Wiley Blackwell (John Wiley & Sons)
• Subjects: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Biostatistics; Breast cancer; Case-Control Studies; Computer Simulation; Humans; joint frailty models; Likelihood Functions; Mortality; nested case–control studies; penalized likelihood; Recurrence; recurrent events; Studies; nested case-control studies; penalized likelihood; recurrent events; joint frailty models

The process by which patients experience a series of recurrent events, such as hospitalizations, may be subject to death. In cohort studies, one strategy for analyzing such data is to fit a joint frailty model for the intensities of the recurrent event and death, which estimates covariate effects on...