Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects

• Published in: Experimental physiology Vol. 99; no. 2; pp. 368 - 380
• Main Authors: Pollak, Kelly A., Swenson, Jeffrey D., Vanhaitsma, Timothy A., Hughen, Ronald W., Jo, Daehyun, Light, Kathleen C., Schweinhardt, Petra, Amann, Markus, Light, Alan R.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2014
• Subjects: Adenosine Triphosphate - metabolism; Adult; Exercise - physiology; Female; Humans; Lactic Acid - metabolism; Male; Middle Aged; Muscle Fatigue - physiology; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Neurons, Afferent - metabolism; Neurons, Afferent - physiology; Pain - metabolism; Pain - physiopathology; Physical Endurance - physiology; Sensation - physiology; Sensory Receptor Cells - metabolism; Sensory Receptor Cells - physiology

New Findings What is the central question of this study? Can physiological concentrations of metabolite combinations evoke sensations of fatigue and pain when injected into skeletal muscle? If so, what sensations are evoked? What is the main finding and its importance? Low concentrations of protons,...