Design principles of biochemical oscillators

• Published in: Nature reviews. Molecular cell biology Vol. 9; no. 12; pp. 981 - 991
• Main Authors: Novák, Béla, Tyson, John J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2008; Nature Publishing Group
• Subjects: Animals; Biochemistry; Biological Clocks - physiology; Biology; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell cycle; Chemical reactions; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Developmental Biology; Embryos; Feedback; Feedback, Physiological - physiology; Genetic aspects; Kinases; Kinetics; Life Sciences; Metabolism; Metabolites; Models, Biological; Oscillators; Oscillatory reactions; Physiological aspects; Physiology; Protein synthesis; Proteins; review-article; Signal Transduction; Stem Cells; Topology; United States; United Kingdom; United States > US; Virginia

Key Points Many physiological behaviours of cells are repeated periodically in time, such as hormone secretion, second messenger signalling, cell-division cycles and circadian rhythms. Oscillatory behaviour is a systems-level property of the interactions of genes, proteins and metabolites in the cel...