Pharmacokinetic Variables of Dapagliflozin/Metformin Extended-release Fixed-dose Combination in Healthy Chinese Volunteers and Regional Comparison

• Published in: Clinical therapeutics Vol. 45; no. 8; pp. 762 - 769
• Main Authors: Zhao, Xiaoying, Ning, Rui, Hui, Andrew, Boulton, David W., Tang, Weifeng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023; Elsevier Limited
• Subjects: Antidiabetics; Bioequivalence; Blood & organ donations; China; Dapagliflozin; Diabetes mellitus (non-insulin dependent); Drug dosages; FDA approval; Fixed-dose combination; Glucose; Hemoglobin; Hyperglycemia; Internal Medicine; Ions; Metformin; Patients; Pharmacokinetics; Plasma; Regional comparisons; Regulatory approval; Safety; Tablets; Volunteers; United States > US; China; Regional comparisons; Metformin; Bioequivalence; Dapagliflozin; Fixed-dose combination; China

A fixed-dose combination (FDC) product combining dapagliflozin and metformin may increase medication adherence in patients with type 2 diabetes mellitus (T2DM) by minimizing pill burden associated with co-administration of individual component (IC) formulations and, consequently, improve cost-effici...