Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure

• Published in: PloS one Vol. 11; no. 8; p. e0160884
• Main Authors: Choi, Youngsok, Kim, Jung Oh, Shim, Sung Han, Lee, Yubin, Kim, Ji Hyang, Jeon, Young Joo, Ko, Jung Jae, Lee, Woo Sik, Kim, Nam Keun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2016; Public Library of Science (PLoS)
• Subjects: Abortion; Abortion, Habitual - ethnology; Abortion, Habitual - genetics; Adult; Asian Continental Ancestry Group - genetics; Biology and Life Sciences; Cancer; Carbon; Deoxyribonucleic acid; DNA; DNA methylation; Embryo Implantation; Embryos; Enhancer Elements, Genetic - genetics; Enzymes; Female; Fertility; Gene Frequency; Gene polymorphism; Genes; Genetic diversity; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genetic Variation; Genotype; Genotypes; Gynecology; Homocysteine; Humans; Implantation; In vitro fertilization; Infertility; Life sciences; Medical imaging; Medicine; Medicine and Health Sciences; Menstruation; Meta-Analysis as Topic; Metabolism; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Obstetrics; Odds Ratio; Patients; Polymerase Chain Reaction; Polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Protein turnover; Republic of Korea; Restriction fragment length polymorphism; Risk factors; Thymidylate synthase; Thymidylate Synthase - genetics; Thyroid gland; Vitamin B

The one-carbon metabolism pathway disorder was important role in successful pregnancy. The MTHFR and TS protein were crucial factor in one-carbon metabolism. To investigate the association between recurrent implantation failure (RIF) and enzymes in the one-carbon metabolism pathway. A total of 120 w...