Recent Advances in the Use of the Dimerization Strategy as a Means to Increase the Biological Potential of Natural or Synthetic Molecules

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 8; p. 2340
• Main Authors: Paquin, Alexis, Reyes-Moreno, Carlos, Bérubé, Gervais
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.04.2021; MDPI
• Subjects: Androgens; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - therapeutic use; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; antitumor agents; Binding sites; biological activity; Biological Products - chemistry; Biological Products - therapeutic use; C2-symmetry; Design; Dimerization; dimers; drug design; Drugs; Estrogens; Humans; Natural products; Nucleosides - chemistry; Prostate cancer; Review; Steroids; Steroids - chemistry; Structure-Activity Relationship; Symmetry; synthesis; Terpenes - chemistry; Testosterone; synthesis; dimers; C2-symmetry; biological activity; drug design; antitumor agents

The design of C2-symmetric biologically active molecules is a subject of interest to the scientific community. It provides the possibility of discovering medicine with higher biological potential than the parent drugs. Such molecules are generally produced by classic chemistry, considering the short...