Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 3; p. 735
• Main Authors: Economos, Nicholas G., Oyaghire, Stanley, Quijano, Elias, Ricciardi, Adele S., Saltzman, W. Mark, Glazer, Peter M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.02.2020; MDPI
• Subjects: cystic fibrosis; Deoxyribonucleic acid; DNA; gene editing; Genome editing; Investigations; nanoparticles; peptide nucleic acids; Peptides; pna; recombination; repair; Review; structure; triplex; β-thalassemia; repair; PNA; nanoparticles; recombination; cystic fibrosis; gene editing; triplex; structure; β-thalassemia; peptide nucleic acids

Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing. By forming high-affinity heterotriplex structures within the genome, PNAs have been used...