Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 9; p. 847
• Main Authors: Korat, Špela, Bidesi, Natasha Shalina Rajani, Bonanno, Federica, Di Nanni, Adriana, Hoàng, Anh Nguyên Nhât, Herfert, Kristina, Maurer, Andreas, Battisti, Umberto Maria, Bowden, Gregory David, Thonon, David, Vugts, Daniëlle, Windhorst, Albert Dirk, Herth, Matthias Manfred
• Format: Journal Article Web Resource
• Language: English
• Published: Basel MDPI AG 26.08.2021; MDPI
• Subjects: alpha-synuclein; Brain research; Chemistry; Chimie; Clinical trials; DNA repair; Drug Discovery; imaging; Molecular Medicine; Nervous system; Neurodegeneration; Parkinson's disease; Patients; Pharmaceutical Science; Phosphorylation; Physical, chemical, mathematical & earth Sciences; Physique, chimie, mathématiques & sciences de la terre; positron emission tomography; Proteins; Review; synucleinopathies; United States > US

Neurodegenerative diseases such as Parkinson’s disease (PD) are manifested by inclusion bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these inclusions is thus far only possible by histological examination of postmortem brain tissue. The possibility of non-invasively...