Specific serum IgG, but not IgA, antibody against purified Opisthorchis viverrini antigen associated with hepatobiliary disease and cholangiocarcinoma

• Published in: Parasitology international Vol. 61; no. 1; pp. 212 - 216
• Main Authors: Pinlaor, Porntip, Pongsamart, Porntip, Hongsrichan, Nuttanan, Sangka, Arunnee, Srilunchang, Thitima, Mairiang, Eimorn, Sithithaworn, Paiboon, Pinlaor, Somchai
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.03.2012
• Subjects: Adult; Animals; antibodies; Antibodies, Helminth - blood; antigens; Antigens, Helminth - immunology; Bile Duct Neoplasms - blood; Bile Duct Neoplasms - complications; Bile Duct Neoplasms - diagnostic imaging; Bile Duct Neoplasms - immunology; Bile Ducts, Intrahepatic - diagnostic imaging; Bile Ducts, Intrahepatic - immunology; Bile Ducts, Intrahepatic - pathology; Biliary Tract - diagnostic imaging; Biliary Tract - immunology; Biliary Tract - pathology; Biliary Tract Diseases - blood; Biliary Tract Diseases - complications; Biliary Tract Diseases - diagnostic imaging; Biliary Tract Diseases - immunology; blood serum; Cholangiocarcinoma; Cholangiocarcinoma - blood; Cholangiocarcinoma - complications; Cholangiocarcinoma - diagnostic imaging; Cholangiocarcinoma - immunology; chromatography; Chromatography, Gel; Cricetinae; cross reaction; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Fishes - parasitology; Gastroenterology and Hepatology; gels; Hepatobiliary disease; Humans; immunoglobulin A; Immunoglobulin A - blood; immunoglobulin G; Immunoglobulin G - blood; Infectious Disease; Linear Models; liver; Liver - diagnostic imaging; Liver - immunology; Liver - pathology; Liver Diseases - blood; Liver Diseases - complications; Liver Diseases - diagnostic imaging; Liver Diseases - immunology; Male; Middle Aged; Opisthorchiasis - diagnosis; Opisthorchiasis - immunology; Opisthorchis - immunology; Opisthorchis viverrini; parasites; parasitology; regression analysis; risk; screening; serodiagnosis; Species Specificity; Specific IgG and IgA antibodies; Thailand; Ultrasonography; Thailand; Hepatobiliary disease; Opisthorchis viverrini; Cholangiocarcinoma; Specific IgG and IgA antibodies

Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an e...