Specific serum IgG, but not IgA, antibody against purified Opisthorchis viverrini antigen associated with hepatobiliary disease and cholangiocarcinoma
Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an e...
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| Published in | Parasitology international Vol. 61; no. 1; pp. 212 - 216 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ireland Ltd
01.03.2012
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| Abstract | Opisthorchiasis caused by
Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of
O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic
O. viverrini antigen was purified into three fractions (
viz., P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels—against these antigens from subjects with
O. viverrini-positive HBD—higher than in subjects with
O. viverrini-negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA
>
severe HBD
>
mild HBD
>
healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified
O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA.
[Display omitted]
►
O. viverrini infection induces hepatobiliary disease (HBD) leading to cholangiocarcinoma (CCA). ► Parasite-specific antibody may be useful to evaluate the severity of opisthorchiasis. ► The level of IgG against purified fluke antigen was associated with HBD status. ► IgG against purified antigen may be useful for screening opisthorchiasis patients at a risk of CCA. |
|---|---|
| AbstractList | Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic O. viverrini antigen was purified into three fractions (viz., P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels—against these antigens from subjects with O. viverrini-positive HBD—higher than in subjects with O. viverrini-negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA>severe HBD>mild HBD>healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA. Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic O. viverrini antigen was purified into three fractions ( viz., P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels—against these antigens from subjects with O. viverrini-positive HBD—higher than in subjects with O. viverrini-negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA > severe HBD > mild HBD > healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA. [Display omitted] ► O. viverrini infection induces hepatobiliary disease (HBD) leading to cholangiocarcinoma (CCA). ► Parasite-specific antibody may be useful to evaluate the severity of opisthorchiasis. ► The level of IgG against purified fluke antigen was associated with HBD status. ► IgG against purified antigen may be useful for screening opisthorchiasis patients at a risk of CCA. Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic O. viverrini antigen was purified into three fractions (viz., P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels-against these antigens from subjects with O. viverrini-positive HBD-higher than in subjects with O. viverrini-negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA>severe HBD>mild HBD>healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA.Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic O. viverrini antigen was purified into three fractions (viz., P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels-against these antigens from subjects with O. viverrini-positive HBD-higher than in subjects with O. viverrini-negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA>severe HBD>mild HBD>healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA. Abstract Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory immune response. Here, we evaluated specific IgG and IgA antibodies against different fractions of O. viverrini antigen in residents from an endemic community in Northeast Thailand with varying hepatobiliary abnormalities. Crude somatic O. viverrini antigen was purified into three fractions ( viz. , P1, P2 and P3) by gel infiltration chromatography and these served as antigens for detection of fluke-specific IgG and IgA antibodies by enzyme-linked immunosorbent assay (ELISA). The results revealed fluke-specific IgG and IgA antibody levels—against these antigens from subjects with O. viverrini -positive HBD—higher than in subjects with O. viverrini -negative HBD. Interestingly, the rank of fluke-specific IgG (and not IgA) antibody levels against crude extract and P1 antigens was CCA > severe HBD > mild HBD > healthy individuals. Purified antigens reduced cross-reactivity with other parasites compared to the crude antigen. Multiple linear regression analysis showed that HBD status was significantly associated with the liver fluke-specific IgG antibody against purified antigens. These results suggest that purified O. viverrini -antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA. |
| Author | Hongsrichan, Nuttanan Sithithaworn, Paiboon Srilunchang, Thitima Pinlaor, Somchai Mairiang, Eimorn Pinlaor, Porntip Sangka, Arunnee Pongsamart, Porntip |
| Author_xml | – sequence: 1 givenname: Porntip surname: Pinlaor fullname: Pinlaor, Porntip organization: Centre for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 2 givenname: Porntip surname: Pongsamart fullname: Pongsamart, Porntip organization: Centre for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 3 givenname: Nuttanan surname: Hongsrichan fullname: Hongsrichan, Nuttanan organization: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 4 givenname: Arunnee surname: Sangka fullname: Sangka, Arunnee organization: Centre for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 5 givenname: Thitima surname: Srilunchang fullname: Srilunchang, Thitima organization: Centre for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 6 givenname: Eimorn surname: Mairiang fullname: Mairiang, Eimorn organization: Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 7 givenname: Paiboon surname: Sithithaworn fullname: Sithithaworn, Paiboon organization: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand – sequence: 8 givenname: Somchai surname: Pinlaor fullname: Pinlaor, Somchai email: psomec@kku.ac.th organization: Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21718798$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.4269/ajtmh.1978.27.787 10.4269/ajtmh.2002.66.542 10.1016/j.cell.2010.01.025 10.1016/j.ijpara.2008.12.002 10.1111/j.1365-3024.1986.tb00861.x 10.1093/carcin/19.3.485 10.1016/0020-7519(94)00212-7 10.4269/ajtmh.2008.78.564 10.1097/MOG.0b013e3282fbf9b3 10.4269/ajtmh.1994.51.424 10.1093/clinids/21.3.608 10.1111/j.1365-2249.1991.tb08151.x 10.1002/ijc.2910590412 10.1016/j.niox.2004.08.004 10.1016/S1471-4922(03)00139-9 10.1002/hep.23134 10.1046/j.1365-3024.2000.00286.x 10.1093/carcin/bgh157 10.1086/514131 10.1515/BC.2006.049 10.1016/j.exppara.2004.07.007 10.1016/0035-9203(94)90438-3 |
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| Keywords | Hepatobiliary disease Opisthorchis viverrini Cholangiocarcinoma Specific IgG and IgA antibodies |
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| References | Prakobwong, Pinlaor, Yongvanit, Sithithaworn, Pairojkul, Hiraku (bb0085) 2009; 39 Akai, Pungpak, Chaicumpa, Viroj, Bunnag, Befus (bb0095) 1994; 88 Kawanishi, Hiraku, Pinlaor, Ma (bb0030) 2006; 387 Pinlaor, Ma, Hiraku, Yongvanit, Semba, Oikawa (bb0090) 2004; 25 Sakolvaree, Ybanez, Chaicumpa (bb0130) 1997; 15 Flavell, Flavell (bb0015) 1986; 8 Haswell-Elkins, Mairiang, Mairiang, Chaiyakum, Chamadol, Loapaiboon (bb0065) 1994; 59 Sripa, Kaewkes (bb0025) 2000; 22 Poopyruchpong, Viyanant, Upatham, Srivatanakul (bb0135) 1990; 8 Pinlaor, Prakobwong, Hiraku, Kaewsamut, Dechakhamphu, Boonmars (bb0070) 2008; 78 Farah, Borjesson, Kariuki, Yole, Suleman, Hau (bb0120) 2003; 91 Grivennikov, Greten, Karin (bb0075) 2010; 140 Itoh, Pairojkul, Thamawit, Sithithaworn, Tiwawech, Uttaravicien (bb0045) 1994; 51 Sripa, Mairiang, Thinkhamrop, Laha, Kaewkes, Sithithaworn (bb0080) 2009; 50 Sirisinha, Tuti, Vichasri, Tawatsin (bb0050) 1983; 14 Silveira, Bethony, Gazzinelli, Kloos, Fraga, Alvares (bb0115) 2002; 66 Rabello, Garcia, da Silva, Rocha, Chaves, Katz (bb0125) 1995; 21 Sripa, Pairojkul (bb0005) 2008; 24 Grogan, Kremsner, van Dam, Deelder, Yazdanbakhsh (bb0110) 1997; 176 Haswell-Elkins, Sithithaworn, Mairiang, Elkins, Wongratanacheewin, Kaewkes (bb0060) 1991; 84 Srivatanakul, Viyanant, Kurathong, Tiwawech (bb0055) 1985; 16 Bhamarapravati, Thammavit, Vajrasthira (bb0010) 1978; 27 Satarug, Haswell-Elkins, Sithithaworn, Bartsch, Ohshima, Tsuda (bb0020) 1998; 19 Pinlaor, Hiraku, Ma, Yongvanit, Semba, Oikawa (bb0035) 2004; 11 Garraud, Perraut, Riveau, Nutman (bb0105) 2003; 19 Pinlaor, Sripa, Sithithaworn, Yongvanit (bb0100) 2004; 108 Akai, Pungpak, Chaicumpa, Kitikoon, Ruangkunaporn, Bunnag (bb0040) 1995; 25 Pinlaor (10.1016/j.parint.2011.06.014_bb0090) 2004; 25 Sakolvaree (10.1016/j.parint.2011.06.014_bb0130) 1997; 15 Prakobwong (10.1016/j.parint.2011.06.014_bb0085) 2009; 39 Grivennikov (10.1016/j.parint.2011.06.014_bb0075) 2010; 140 Kawanishi (10.1016/j.parint.2011.06.014_bb0030) 2006; 387 Satarug (10.1016/j.parint.2011.06.014_bb0020) 1998; 19 Srivatanakul (10.1016/j.parint.2011.06.014_bb0055) 1985; 16 Sirisinha (10.1016/j.parint.2011.06.014_bb0050) 1983; 14 Itoh (10.1016/j.parint.2011.06.014_bb0045) 1994; 51 Poopyruchpong (10.1016/j.parint.2011.06.014_bb0135) 1990; 8 Sripa (10.1016/j.parint.2011.06.014_bb0005) 2008; 24 Haswell-Elkins (10.1016/j.parint.2011.06.014_bb0065) 1994; 59 Rabello (10.1016/j.parint.2011.06.014_bb0125) 1995; 21 Farah (10.1016/j.parint.2011.06.014_bb0120) 2003; 91 Akai (10.1016/j.parint.2011.06.014_bb0040) 1995; 25 Bhamarapravati (10.1016/j.parint.2011.06.014_bb0010) 1978; 27 Akai (10.1016/j.parint.2011.06.014_bb0095) 1994; 88 Haswell-Elkins (10.1016/j.parint.2011.06.014_bb0060) 1991; 84 Sripa (10.1016/j.parint.2011.06.014_bb0080) 2009; 50 Silveira (10.1016/j.parint.2011.06.014_bb0115) 2002; 66 Pinlaor (10.1016/j.parint.2011.06.014_bb0070) 2008; 78 Sripa (10.1016/j.parint.2011.06.014_bb0025) 2000; 22 Pinlaor (10.1016/j.parint.2011.06.014_bb0035) 2004; 11 Grogan (10.1016/j.parint.2011.06.014_bb0110) 1997; 176 Flavell (10.1016/j.parint.2011.06.014_bb0015) 1986; 8 Pinlaor (10.1016/j.parint.2011.06.014_bb0100) 2004; 108 Garraud (10.1016/j.parint.2011.06.014_bb0105) 2003; 19 |
| References_xml | – volume: 16 start-page: 234 year: 1985 end-page: 239 ident: bb0055 article-title: Enzyme-linked immunosorbent assay for detection of publication-title: Southeast Asian J Trop Med Public Health – volume: 25 start-page: 1535 year: 2004 end-page: 1542 ident: bb0090 article-title: Repeated infection with publication-title: Carcinogenesis – volume: 15 start-page: 115 year: 1997 end-page: 122 ident: bb0130 article-title: Parasites elicited cross-reacting antibodies to publication-title: Asian Pac J Allergy Immunol – volume: 8 start-page: 455 year: 1986 end-page: 466 ident: bb0015 publication-title: Parasite Immunol – volume: 14 start-page: 243 year: 1983 end-page: 251 ident: bb0050 article-title: Humoral immune responses in hamsters infected with publication-title: Southeast Asian J Trop Med Public Health – volume: 19 start-page: 300 year: 2003 end-page: 304 ident: bb0105 article-title: Class and subclass selection in parasite-specific antibody responses publication-title: Trends Parasitol – volume: 88 start-page: 471 year: 1994 end-page: 474 ident: bb0095 article-title: Serum antibody response to publication-title: Trans R Soc Trop Med Hyg – volume: 8 start-page: 27 year: 1990 end-page: 31 ident: bb0135 article-title: Diagnosis of opisthorchiasis by enzyme-linked immunosorbent assay using partially purified antigens publication-title: Asian Pac J Allergy Immunol – volume: 84 start-page: 213 year: 1991 end-page: 218 ident: bb0060 article-title: Immune responsiveness and parasite-specific antibody levels in human hepatobiliary disease associated with publication-title: Clin Exp Immunol – volume: 176 start-page: 1344 year: 1997 end-page: 1350 ident: bb0110 article-title: Anti-schistosome IgG4 and IgE at 2 publication-title: J Infect Dis – volume: 39 start-page: 825 year: 2009 end-page: 835 ident: bb0085 article-title: Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with publication-title: Int J Parasitol – volume: 59 start-page: 505 year: 1994 end-page: 509 ident: bb0065 article-title: Cross-sectional study of publication-title: Int J Cancer – volume: 24 start-page: 349 year: 2008 end-page: 356 ident: bb0005 article-title: Cholangiocarcinoma: lessons from Thailand publication-title: Curr Opin Gastroenterol – volume: 387 start-page: 365 year: 2006 end-page: 372 ident: bb0030 article-title: Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis publication-title: Biol Chem – volume: 11 start-page: 175 year: 2004 end-page: 183 ident: bb0035 article-title: Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with publication-title: Nitric Oxide – volume: 91 start-page: 344 year: 2003 end-page: 348 ident: bb0120 article-title: Morbidity and immune response to natural schistosomiasis in baboons ( publication-title: Parasitol Res – volume: 21 start-page: 608 year: 1995 end-page: 615 ident: bb0125 article-title: Humoral immune responses in acute schistosomiasis mansoni: relation to morbidity publication-title: Clin Infect Dis – volume: 140 start-page: 883 year: 2010 end-page: 899 ident: bb0075 article-title: Immunity, inflammation, and cancer publication-title: Cell – volume: 78 start-page: 564 year: 2008 end-page: 573 ident: bb0070 article-title: Oxidative and nitrative stress in publication-title: Am J Trop Med Hyg – volume: 27 start-page: 787 year: 1978 end-page: 794 ident: bb0010 article-title: Liver changes in hamsters infected with a liver fluke of man, publication-title: Am J Trop Med Hyg – volume: 22 start-page: 139 year: 2000 end-page: 145 ident: bb0025 article-title: Relationship between parasite-specific antibody responses and intensity of publication-title: Parasite Immunol – volume: 50 start-page: 1273 year: 2009 end-page: 1281 ident: bb0080 article-title: Advanced periductal fibrosis from infection with the carcinogenic human liver fluke publication-title: Hepatology – volume: 51 start-page: 424 year: 1994 end-page: 429 ident: bb0045 article-title: Association of antibodies to publication-title: Am J Trop Med Hyg – volume: 25 start-page: 971 year: 1995 end-page: 973 ident: bb0040 article-title: Serum antibody responses in opisthorchiasis publication-title: Int J Parasitol – volume: 108 start-page: 32 year: 2004 end-page: 39 ident: bb0100 article-title: Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with publication-title: Exp Parasitol – volume: 19 start-page: 485 year: 1998 end-page: 491 ident: bb0020 article-title: Relationships between the synthesis of publication-title: Carcinogenesis – volume: 66 start-page: 542 year: 2002 end-page: 549 ident: bb0115 article-title: High levels of IgG4 to publication-title: Am J Trop Med Hyg – volume: 27 start-page: 787 year: 1978 ident: 10.1016/j.parint.2011.06.014_bb0010 article-title: Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.1978.27.787 – volume: 66 start-page: 542 year: 2002 ident: 10.1016/j.parint.2011.06.014_bb0115 article-title: High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2002.66.542 – volume: 15 start-page: 115 year: 1997 ident: 10.1016/j.parint.2011.06.014_bb0130 article-title: Parasites elicited cross-reacting antibodies to Opisthorchis viverrini publication-title: Asian Pac J Allergy Immunol – volume: 140 start-page: 883 year: 2010 ident: 10.1016/j.parint.2011.06.014_bb0075 article-title: Immunity, inflammation, and cancer publication-title: Cell doi: 10.1016/j.cell.2010.01.025 – volume: 39 start-page: 825 year: 2009 ident: 10.1016/j.parint.2011.06.014_bb0085 article-title: Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury publication-title: Int J Parasitol doi: 10.1016/j.ijpara.2008.12.002 – volume: 8 start-page: 455 year: 1986 ident: 10.1016/j.parint.2011.06.014_bb0015 article-title: Opisthorchis viverrini: pathogenesis of infection in immunodeprived hamsters publication-title: Parasite Immunol doi: 10.1111/j.1365-3024.1986.tb00861.x – volume: 16 start-page: 234 year: 1985 ident: 10.1016/j.parint.2011.06.014_bb0055 article-title: Enzyme-linked immunosorbent assay for detection of Opisthorchis viverrini infection publication-title: Southeast Asian J Trop Med Public Health – volume: 19 start-page: 485 year: 1998 ident: 10.1016/j.parint.2011.06.014_bb0020 article-title: Relationships between the synthesis of N-nitrosodimethylamine and immune responses to chronic infection with the carcinogenic parasite, Opisthorchis viverrini, in men publication-title: Carcinogenesis doi: 10.1093/carcin/19.3.485 – volume: 25 start-page: 971 year: 1995 ident: 10.1016/j.parint.2011.06.014_bb0040 article-title: Serum antibody responses in opisthorchiasis publication-title: Int J Parasitol doi: 10.1016/0020-7519(94)00212-7 – volume: 78 start-page: 564 year: 2008 ident: 10.1016/j.parint.2011.06.014_bb0070 article-title: Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2008.78.564 – volume: 24 start-page: 349 year: 2008 ident: 10.1016/j.parint.2011.06.014_bb0005 article-title: Cholangiocarcinoma: lessons from Thailand publication-title: Curr Opin Gastroenterol doi: 10.1097/MOG.0b013e3282fbf9b3 – volume: 51 start-page: 424 year: 1994 ident: 10.1016/j.parint.2011.06.014_bb0045 article-title: Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.1994.51.424 – volume: 21 start-page: 608 year: 1995 ident: 10.1016/j.parint.2011.06.014_bb0125 article-title: Humoral immune responses in acute schistosomiasis mansoni: relation to morbidity publication-title: Clin Infect Dis doi: 10.1093/clinids/21.3.608 – volume: 84 start-page: 213 year: 1991 ident: 10.1016/j.parint.2011.06.014_bb0060 article-title: Immune responsiveness and parasite-specific antibody levels in human hepatobiliary disease associated with Opisthorchis viverrini infection publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.1991.tb08151.x – volume: 59 start-page: 505 year: 1994 ident: 10.1016/j.parint.2011.06.014_bb0065 article-title: Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand publication-title: Int J Cancer doi: 10.1002/ijc.2910590412 – volume: 11 start-page: 175 year: 2004 ident: 10.1016/j.parint.2011.06.014_bb0035 article-title: Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis publication-title: Nitric Oxide doi: 10.1016/j.niox.2004.08.004 – volume: 19 start-page: 300 year: 2003 ident: 10.1016/j.parint.2011.06.014_bb0105 article-title: Class and subclass selection in parasite-specific antibody responses publication-title: Trends Parasitol doi: 10.1016/S1471-4922(03)00139-9 – volume: 14 start-page: 243 year: 1983 ident: 10.1016/j.parint.2011.06.014_bb0050 article-title: Humoral immune responses in hamsters infected with Opisthorchis viverrini publication-title: Southeast Asian J Trop Med Public Health – volume: 91 start-page: 344 year: 2003 ident: 10.1016/j.parint.2011.06.014_bb0120 article-title: Morbidity and immune response to natural schistosomiasis in baboons (Papio anubis) publication-title: Parasitol Res – volume: 8 start-page: 27 year: 1990 ident: 10.1016/j.parint.2011.06.014_bb0135 article-title: Diagnosis of opisthorchiasis by enzyme-linked immunosorbent assay using partially purified antigens publication-title: Asian Pac J Allergy Immunol – volume: 50 start-page: 1273 year: 2009 ident: 10.1016/j.parint.2011.06.014_bb0080 article-title: Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6 publication-title: Hepatology doi: 10.1002/hep.23134 – volume: 22 start-page: 139 year: 2000 ident: 10.1016/j.parint.2011.06.014_bb0025 article-title: Relationship between parasite-specific antibody responses and intensity of Opisthorchis viverrini infection in hamsters publication-title: Parasite Immunol doi: 10.1046/j.1365-3024.2000.00286.x – volume: 25 start-page: 1535 year: 2004 ident: 10.1016/j.parint.2011.06.014_bb0090 article-title: Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase publication-title: Carcinogenesis doi: 10.1093/carcin/bgh157 – volume: 176 start-page: 1344 year: 1997 ident: 10.1016/j.parint.2011.06.014_bb0110 article-title: Anti-schistosome IgG4 and IgE at 2years after chemotherapy: infected versus uninfected individuals publication-title: J Infect Dis doi: 10.1086/514131 – volume: 387 start-page: 365 year: 2006 ident: 10.1016/j.parint.2011.06.014_bb0030 article-title: Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis publication-title: Biol Chem doi: 10.1515/BC.2006.049 – volume: 108 start-page: 32 year: 2004 ident: 10.1016/j.parint.2011.06.014_bb0100 article-title: Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with Opisthorchis viverrini publication-title: Exp Parasitol doi: 10.1016/j.exppara.2004.07.007 – volume: 88 start-page: 471 year: 1994 ident: 10.1016/j.parint.2011.06.014_bb0095 article-title: Serum antibody response to Opisthorchis viverrini antigen as a marker for opisthorchiasis-associated cholangiocarcinoma publication-title: Trans R Soc Trop Med Hyg doi: 10.1016/0035-9203(94)90438-3 |
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Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory... Abstract Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic... Opisthorchiasis caused by Opisthorchis viverrini infection induces hepatobiliary disease (HBD)-associated cholangiocarcinoma (CCA) via a chronic inflammatory... |
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| SubjectTerms | Adult Animals antibodies Antibodies, Helminth - blood antigens Antigens, Helminth - immunology Bile Duct Neoplasms - blood Bile Duct Neoplasms - complications Bile Duct Neoplasms - diagnostic imaging Bile Duct Neoplasms - immunology Bile Ducts, Intrahepatic - diagnostic imaging Bile Ducts, Intrahepatic - immunology Bile Ducts, Intrahepatic - pathology Biliary Tract - diagnostic imaging Biliary Tract - immunology Biliary Tract - pathology Biliary Tract Diseases - blood Biliary Tract Diseases - complications Biliary Tract Diseases - diagnostic imaging Biliary Tract Diseases - immunology blood serum Cholangiocarcinoma Cholangiocarcinoma - blood Cholangiocarcinoma - complications Cholangiocarcinoma - diagnostic imaging Cholangiocarcinoma - immunology chromatography Chromatography, Gel Cricetinae cross reaction Cross Reactions Enzyme-Linked Immunosorbent Assay Female Fishes - parasitology Gastroenterology and Hepatology gels Hepatobiliary disease Humans immunoglobulin A Immunoglobulin A - blood immunoglobulin G Immunoglobulin G - blood Infectious Disease Linear Models liver Liver - diagnostic imaging Liver - immunology Liver - pathology Liver Diseases - blood Liver Diseases - complications Liver Diseases - diagnostic imaging Liver Diseases - immunology Male Middle Aged Opisthorchiasis - diagnosis Opisthorchiasis - immunology Opisthorchis - immunology Opisthorchis viverrini parasites parasitology regression analysis risk screening serodiagnosis Species Specificity Specific IgG and IgA antibodies Thailand Ultrasonography |
| Title | Specific serum IgG, but not IgA, antibody against purified Opisthorchis viverrini antigen associated with hepatobiliary disease and cholangiocarcinoma |
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