Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and its Implication for Treatment Resistance

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 1; pp. 160 - 171
• Main Authors: STANTON, Marissa J, DUTTA, Samikshan, HEYU ZHANG, POLAVARAM, Navatha S, LEONTOVICH, Alexey A, HÖNSCHEID, Pia, SINICROPE, Frank A, TINDALL, Donald J, MUDERS, Michael H, DATTA, Kaustubh
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.01.2013
• Subjects: Antineoplastic agents; Apoptosis - physiology; Autophagy - genetics; Biological and medical sciences; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm - genetics; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic - genetics; Humans; Medical sciences; Microscopy, Confocal; Neoplasms - genetics; Neoplasms - metabolism; Neuropilin-2 - genetics; Neuropilin-2 - metabolism; Oligonucleotide Array Sequence Analysis; Pharmacology. Drug treatments; Real-Time Polymerase Chain Reaction; Signal Transduction - genetics; Transfection; Tumors; Vascular Endothelial Growth Factor C - genetics; Vascular Endothelial Growth Factor C - metabolism; Control; Treatment resistance; Vascular endothelium growth factor; Vascular endothelial growth factor C; Malignant tumor; Autophagy; Cancer

A major contributor to cancer mortality is recurrence and subsequent metastatic transformation following therapeutic intervention. Therefore, in order to develop new treatment modalities and improve the efficacy of current ones, it is important to understand the molecular mechanisms that promote res...